Literature DB >> 2450783

Bleomycin resistance conferred by a drug-binding protein.

A Gatignol1, H Durand, G Tiraby.   

Abstract

The protein coded by a bleomycin-resistance gene (ble) cloned from producing actinomycetes was purified from a culture of a recombinant E. coli strain and its action on bleomycin was determined by in vitro assays. The protein binds reversibly in a one to one ratio to bleomycin which can no longer cleave DNA. The bleomycin resistance of cells harboring a ble gene could be accounted for by a sequestering effect of the bleomycin-binding protein.

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Year:  1988        PMID： 2450783     DOI： 10.1016/0014-5793(88)80665-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  58 in total

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