Literature DB >> 24506882

Translational research: the path for bringing discovery to patients.

Leonard Zon1.   

Abstract

Translating basic research findings into therapeutic settings presents many scientific, logistic, and financial challenges for academic researchers. Here, I highlight some key insights for navigating such challenges based on recent clinical trials initiated by basic research from my lab.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24506882      PMCID： PMC5972520          DOI： 10.1016/j.stem.2014.01.004

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  4 in total

1.  Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models.

Authors:  Wolfram Goessling; Robyn S Allen; Xiao Guan; Ping Jin; Naoya Uchida; Michael Dovey; James M Harris; Mark E Metzger; Aylin C Bonifacino; David Stroncek; Joseph Stegner; Myriam Armant; Thorsten Schlaeger; John F Tisdale; Leonard I Zon; Robert E Donahue; Trista E North
Journal:  Cell Stem Cell       Date:  2011-04-08       Impact factor: 24.633

2.  Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation.

Authors:  Jonathan Hoggatt; Pratibha Singh; Janardhan Sampath; Louis M Pelus
Journal:  Blood       Date:  2009-03-26       Impact factor: 22.113

3.  Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.

Authors:  Trista E North; Wolfram Goessling; Carl R Walkley; Claudia Lengerke; Kamden R Kopani; Allegra M Lord; Gerhard J Weber; Teresa V Bowman; Il-Ho Jang; Tilo Grosser; Garret A Fitzgerald; George Q Daley; Stuart H Orkin; Leonard I Zon
Journal:  Nature       Date:  2007-06-21       Impact factor: 49.962

4.  Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Authors:  Corey Cutler; Pratik Multani; David Robbins; Haesook T Kim; Thuy Le; Jonathan Hoggatt; Louis M Pelus; Caroline Desponts; Yi-Bin Chen; Betsy Rezner; Philippe Armand; John Koreth; Brett Glotzbecker; Vincent T Ho; Edwin Alyea; Marlisa Isom; Grace Kao; Myriam Armant; Leslie Silberstein; Peirong Hu; Robert J Soiffer; David T Scadden; Jerome Ritz; Wolfram Goessling; Trista E North; John Mendlein; Karen Ballen; Leonard I Zon; Joseph H Antin; Daniel D Shoemaker
Journal:  Blood       Date:  2013-08-30       Impact factor: 22.113
  4 in total
  6 in total

Review 1.  Zebrafish models in neuropsychopharmacology and CNS drug discovery.

Authors:  Kanza M Khan; Adam D Collier; Darya A Meshalkina; Elana V Kysil; Sergey L Khatsko; Tatyana Kolesnikova; Yury Yu Morzherin; Jason E Warnick; Allan V Kalueff; David J Echevarria
Journal:  Br J Pharmacol       Date:  2017-04-05       Impact factor: 8.739

Review 2.  Advancements in zebrafish applications for 21st century toxicology.

Authors:  Gloria R Garcia; Pamela D Noyes; Robert L Tanguay
Journal:  Pharmacol Ther       Date:  2016-03-22       Impact factor: 12.310

Review 3.  LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.

Authors:  Philipp Gut; Sven Reischauer; Didier Y R Stainier; Rima Arnaout
Journal:  Physiol Rev       Date:  2017-07-01       Impact factor: 37.312

4.  Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.

Authors:  Zahra Kazemi; Christian Bergmayr; Michaela Prchal-Murphy; Tahereh Javaheri; Madeleine Themanns; Ha T T Pham; Wolfgang Strohmaier; Veronika Sexl; Michael Freissmuth; Eva Zebedin-Brandl
Journal:  Mol Pharmacol       Date:  2016-03-17       Impact factor: 4.436

Review 5.  Cross-species models of human melanoma.

Authors:  Louise van der Weyden; E Elizabeth Patton; Geoffrey A Wood; Alastair K Foote; Thomas Brenn; Mark J Arends; David J Adams
Journal:  J Pathol       Date:  2015-10-09       Impact factor: 7.996

Review 6.  Remodeling the Human Adult Stem Cell Niche for Regenerative Medicine Applications.

Authors:  Silvana Bardelli; Marco Moccetti
Journal:  Stem Cells Int       Date:  2017-09-27       Impact factor: 5.443
  6 in total

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