Damien Barbeau1, Renaud Persoons2, Marie Marques3, Claire Hervé2, Gilbert Laffitte-Rigaud4, Anne Maitre5. 1. 1.EPSP, TIMC-IMAG, Université Joseph Fourier de Grenoble, 38700 La Tronche, France 2.Laboratoire de Toxicologie Professionnelle et Environnementale, DBTP, CHU de Grenoble, 38043 Grenoble, France. 2. 2.Laboratoire de Toxicologie Professionnelle et Environnementale, DBTP, CHU de Grenoble, 38043 Grenoble, France. 3. 1.EPSP, TIMC-IMAG, Université Joseph Fourier de Grenoble, 38700 La Tronche, France. 4. 3.Aluminum Pechiney, Rio Tinto Alcan, 73300 Saint Jean de Maurienne, France 4.FerroPem, 73870 Montricher, France. 5. 1.EPSP, TIMC-IMAG, Université Joseph Fourier de Grenoble, 38700 La Tronche, France 2.Laboratoire de Toxicologie Professionnelle et Environnementale, DBTP, CHU de Grenoble, 38043 Grenoble, France anne.maitre@ujf-grenoble.fr.
Abstract
OBJECTIVES: In metallurgy, workers are exposed to mixtures of polycyclic aromatic hydrocarbons (PAHs) in which some compounds are carcinogenic. Biomonitoring of PAH exposure has been performed by measuring urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene which is not carcinogenic. This study investigated the use of 3-hydroxybenzo(a)pyrene (3-OHBaP), a metabolite of benzo(a)pyrene (BaP) which is the main carcinogenic component in PAHs, to improve carcinogen exposure assessment. METHODS: We included 129 metallurgy workers routinely exposed to PAHs during working hours. Urinary samples were collected at three sampling times at the beginning and at the end of the working week for 1-OHP and 3-OHBaP analyses. RESULTS: Workers in anode production showed greater exposure to both biomarkers than those in cathode or silicon production, with respectively, 71, 40, and 30% of 3-OHBaP concentrations exceeding the value of 0.4 nmol mol(-1) creatinine. No difference was observed between the 3-OHBaP levels found at the end of the penultimate workday shift and those at the beginning of the last workday shift. Within these plants, the 1-OHP/3-OHBaP ratios varied greatly according to the workers' activity and emission sources. Using linear regression between these two metabolites, the 1-OHP level corresponding to the guidance value for 3-OHBaP ranged from 0.7 to 2.4 µmol mol(-1) creatinine, depending on the industrial sector. CONCLUSIONS: This study emphasizes the interest of monitoring urinary 3-OHBaP at the end of the last workday shift when working week exposure is relatively steady, and the irrelevance of a single guideline value for 1-OHP when assessing occupational health risk.
OBJECTIVES: In metallurgy, workers are exposed to mixtures of polycyclic aromatic hydrocarbons (PAHs) in which some compounds are carcinogenic. Biomonitoring of PAH exposure has been performed by measuring urinary 1-hydroxypyrene (1-OHP), a metabolite of pyrene which is not carcinogenic. This study investigated the use of 3-hydroxybenzo(a)pyrene (3-OHBaP), a metabolite of benzo(a)pyrene (BaP) which is the main carcinogenic component in PAHs, to improve carcinogen exposure assessment. METHODS: We included 129 metallurgy workers routinely exposed to PAHs during working hours. Urinary samples were collected at three sampling times at the beginning and at the end of the working week for 1-OHP and 3-OHBaP analyses. RESULTS: Workers in anode production showed greater exposure to both biomarkers than those in cathode or silicon production, with respectively, 71, 40, and 30% of 3-OHBaP concentrations exceeding the value of 0.4 nmol mol(-1) creatinine. No difference was observed between the 3-OHBaP levels found at the end of the penultimate workday shift and those at the beginning of the last workday shift. Within these plants, the 1-OHP/3-OHBaP ratios varied greatly according to the workers' activity and emission sources. Using linear regression between these two metabolites, the 1-OHP level corresponding to the guidance value for 3-OHBaP ranged from 0.7 to 2.4 µmol mol(-1) creatinine, depending on the industrial sector. CONCLUSIONS: This study emphasizes the interest of monitoring urinary 3-OHBaP at the end of the last workday shift when working week exposure is relatively steady, and the irrelevance of a single guideline value for 1-OHP when assessing occupational health risk.
Authors: F J van Schooten; F J Jongeneelen; M J Hillebrand; F E van Leeuwen; A J de Looff; A P Dijkmans; J G van Rooij; L den Engelse; E Kriek Journal: Cancer Epidemiol Biomarkers Prev Date: 1995 Jan-Feb Impact factor: 4.254
Authors: Damien Barbeau; Simon Lutier; Vincent Bonneterre; Renaud Persoons; Marie Marques; Claire Herve; Anne Maitre Journal: Int Arch Occup Environ Health Date: 2015-03-06 Impact factor: 3.015
Authors: Ángeles C Ochoa-Martínez; Tania Ruíz-Vera; Lucia G Pruneda-Álvarez; Ana K González-Palomo; Claudia I Almendarez-Reyna; Francisco J Pérez-Vázquez; Iván N Pérez-Maldonado Journal: Environ Sci Pollut Res Int Date: 2016-10-31 Impact factor: 4.223
Authors: Marta Oliveira; Sílvia Capelas; Cristina Delerue-Matos; Simone Morais Journal: Int J Environ Res Public Health Date: 2020-12-30 Impact factor: 3.390
Authors: Angelina Pena; Sofia Duarte; André M P T Pereira; Liliana J G Silva; Célia S M Laranjeiro; Marta Oliveira; Celeste Lino; Simone Morais Journal: Molecules Date: 2021-12-31 Impact factor: 4.411
Authors: Henriqueta Louro; Bruno Costa Gomes; Anne Thoustrup Saber; Anna Laura Iamiceli; Thomas Göen; Kate Jones; Andromachi Katsonouri; Christiana M Neophytou; Ulla Vogel; Célia Ventura; Axel Oberemm; Radu Corneliu Duca; Mariana F Fernandez; Nicolas Olea; Tiina Santonen; Susana Viegas; Maria João Silva Journal: Toxics Date: 2022-08-17