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Literature DB >> 2450163

A physical map of the human regulator of complement activation gene cluster linking the complement genes CR1, CR2, DAF, and C4BP.

J Rey-Campos¹, P Rubinstein, S Rodriguez de Cordoba.

Abstract

We report the organization of the human genes encoding the complement components C4-binding protein (C4BP), C3b/C4b receptor (CR1), decay accelerating factor (DAF), and C3dg receptor (CR2) within the regulator of complement activation (RCA) gene cluster. Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR1-CR2-DAF-C4BP in an 800-kb DNA segment. The very tight linkage between the CR1 and the C4BP loci, contrasted with the relative long DNA distance between these genes, suggests the existence of mechanisms interfering with recombination within the RCA gene cluster.

Entities: Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2450163 PMCID： PMC2188826 DOI： 10.1084/jem.167.2.664

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

19 in total

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Journal: Biochem J Date: 1985-08-15 Impact factor: 3.857

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6. Molecular analysis of the Duchenne muscular dystrophy region using pulsed field gel electrophoresis.

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Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

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Journal: Biochemistry Date: 1987-07-28 Impact factor: 3.162

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Journal: Fed Proc Date: 1987-05-15

10. Human genes for three complement components that regulate the activation of C3 are tightly linked.

Authors: S Rodriguez de Cordoba; D M Lublin; P Rubinstein; J P Atkinson
Journal: J Exp Med Date: 1985-05-01 Impact factor: 14.307

33 in total

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Authors: S R Barnum
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Journal: Proc Natl Acad Sci U S A Date: 1990-02 Impact factor: 11.205

5. Engineering of recombinant soluble CD46: an inhibitor of complement activation.

Authors: D Christiansen; J Milland; B R Thorley; I F McKenzie; P L Mottram; L J Purcell; B E Loveland
Journal: Immunology Date: 1996-03 Impact factor: 7.397

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Authors: S Rodriguez de Cordoba; J Rey-Campos; D D Dykes; P J McAlpine; P Wong; P Rubinstein
Journal: Immunogenetics Date: 1988 Impact factor: 2.846

7. Humoral response to herpes simplex virus is complement-dependent.

Authors: X J Da Costa; M A Brockman; E Alicot; M Ma; M B Fischer; X Zhou; D M Knipe; M C Carroll
Journal: Proc Natl Acad Sci U S A Date: 1999-10-26 Impact factor: 11.205

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Authors: F Pardo-Manuel; J Rey-Campos; A Hillarp; B Dahlbäck; S Rodriguez de Cordoba
Journal: Proc Natl Acad Sci U S A Date: 1990-06 Impact factor: 11.205

9. A linkage map of mouse chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation.

Authors: M L Watson; P D'Eustachio; B A Mock; A D Steinberg; H C Morse; R J Oakey; T A Howard; J M Rochelle; M F Seldin
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Journal: Nat Rev Nephrol Date: 2016-07-25 Impact factor: 28.314