| Literature DB >> 3782802 |
J H Weis, C C Morton, G A Bruns, J J Weis, L B Klickstein, W W Wong, D T Fearon.
Abstract
The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.Entities:
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Year: 1987 PMID： 3782802
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422