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Literature DB >> 3157763

Human genes for three complement components that regulate the activation of C3 are tightly linked.

S Rodriguez de Cordoba, D M Lublin, P Rubinstein, J P Atkinson.

Abstract

A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1985 PMID： 3157763 PMCID： PMC2187593 DOI： 10.1084/jem.161.5.1189

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

22 in total

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56 in total

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Journal: J Biol Chem Date: 2013-11-08 Impact factor: 5.157

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Authors: Jorge Esparza-Gordillo; José Manuel Soria; Alfonso Buil; Laura Almasy; John Blangero; Jordi Fontcuberta; Santiago Rodríguez de Córdoba
Journal: Immunogenetics Date: 2004-04-30 Impact factor: 2.846

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Authors: Christoph Q Schmidt; Andrew P Herbert; Haydyn D T Mertens; Mara Guariento; Dinesh C Soares; Dusan Uhrin; Arthur J Rowe; Dmitri I Svergun; Paul N Barlow
Journal: J Mol Biol Date: 2009-10-14 Impact factor: 5.469