| Literature DB >> 24493794 |
Christina T L Chen1, Ching-Ti Liu2, Gary K Chen3, Jeanette S Andrews4, Alice M Arnold5, Jill Dreyfus6, Nora Franceschini7, Melissa E Garcia8, Kathleen F Kerr5, Guo Li9, Kurt K Lohman4, Solomon K Musani10, Michael A Nalls11, Leslie J Raffel12, Jennifer Smith13, Christine B Ambrosone14, Elisa V Bandera15, Leslie Bernstein16, Angela Britton11, Robert G Brzyski17, Anne Cappola18, Christopher S Carlson19, David Couper20, Sandra L Deming21, Mark O Goodarzi22, Gerardo Heiss7, Esther M John23, Xiaoning Lu24, Loic Le Marchand25, Kristin Marciante9, Barbara Mcknight5, Robert Millikan26, Nora L Nock27, Andrew F Olshan26, Michael F Press28, Dhananjay Vaiyda29, Nancy F Woods30, Herman A Taylor10, Wei Zhao13, Wei Zheng21, Michele K Evans31, Tamara B Harris8, Brian E Henderson3, Sharon L R Kardia13, Charles Kooperberg19, Yongmei Liu32, Thomas H Mosley33, Bruce Psaty34, Melissa Wellons35, Beverly G Windham33, Alan B Zonderman36, L Adrienne Cupples2, Ellen W Demerath6, Christopher Haiman37, Joanne M Murabito38, Aleksandar Rajkovic39.
Abstract
Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.Entities:
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Year: 2014 PMID： 24493794 PMCID： PMC4030781 DOI： 10.1093/hmg/ddu041
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150