Literature DB >> 24485508

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.

Sung Hoon Baik1, Moon-Yong Cha1, Young-Min Hyun2, Hansang Cho3, Bashar Hamza3, Dong Kyu Kim1, Sun-Ho Han1, Heesun Choi1, Kyung Ho Kim1, Minho Moon1, Jeewoo Lee4, Minsoo Kim5, Daniel Irimia3, Inhee Mook-Jung6.   

Abstract

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Amyloid plaques; Immune cells; Neutrophils

Mesh：

Year:  2014        PMID： 24485508      PMCID： PMC4248665          DOI： 10.1016/j.neurobiolaging.2014.01.003

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  18 in total

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2.  Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

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3.  Amyloid-beta induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain.

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Journal:  J Biol Chem       Date:  2001-04-20       Impact factor: 5.157

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8.  Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.

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Review 10.  Neutrophils in animal models of autoimmune disease.

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