Literature DB >> 25674199

Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.

Chang Liu1, Guohong Cui2, Meiping Zhu3, Xiangping Kang4, Haidong Guo5.   

Abstract

Chemokines secreted by astrocytes play multiple roles in the pathology of Alzheimer's disease, a chronic inflammation disorder of central nervous system. The level of chemokines in serum, cerebrospinal fluid and brain tissue and their receptors both significantly changed in patients with Alzheimer's disease. In this review, we briefly summarized the involvement of astrocytes and chemokines in Alzheimer's disease, and the role of chemokine/chemokine receptors in the occurrence and development of Alzheimer's disease. Clarification of the involvement of chemokines and their receptors, such as MCP-1/CCR2, fractalkine/CX3CR1, SDF-1α/CXCR4, MIP-1α/CCR5, IP-10/CXCR3, IL-8/CXCR1, CXCR2, and RANTES/CCR1, CCR3, CCR5, will provide a new strategy and more specific targets for the treatment of Alzheimer's disease.

Entities:  

Keywords:  Alzheimer’s disease; astrocytes; chemokine receptors; chemokines; inflammation

Mesh：

Substances：

Year:  2014        PMID： 25674199      PMCID： PMC4314046     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  121 in total

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4.  Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity.

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5.  Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes.

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7.  Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1.

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Journal:  J Neurochem       Date:  1999-12       Impact factor: 5.372

Review 8.  Chemokine and chemokine receptor expression in the central nervous system.

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Journal:  J Neurovirol       Date:  1999-02       Impact factor: 2.643

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Journal:  Glia       Date:  1999-12       Impact factor: 7.452

10.  CXC and CC chemokine receptors on coronary and brain endothelia.

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Authors:  Donovan A McGrowder; Fabian Miller; Kurt Vaz; Chukwuemeka Nwokocha; Cameil Wilson-Clarke; Melisa Anderson-Cross; Jabari Brown; Lennox Anderson-Jackson; Lowen Williams; Lyndon Latore; Rory Thompson; Ruby Alexander-Lindo
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Review 3.  Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease.

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4.  Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β signaling pathway.

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Review 5.  Glial biomarkers in human central nervous system disease.

Authors:  Gwenn A Garden; Brian M Campbell
Journal:  Glia       Date:  2016-05-26       Impact factor: 7.452

6.  Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation.

Authors:  Kakulavarapu V Rama Rao; Tammy Kielian
Journal:  Clin Exp Neuroimmunol       Date:  2015-08-03

Review 7.  Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation.

Authors:  Tee Jong Huat; Judith Camats-Perna; Estella A Newcombe; Nicholas Valmas; Masashi Kitazawa; Rodrigo Medeiros
Journal:  J Mol Biol       Date:  2019-01-18       Impact factor: 5.469

8.  The Inflammatory Marker YKL-40 Is Elevated in Cerebrospinal Fluid from Patients with Alzheimer's but Not Parkinson's Disease or Dementia with Lewy Bodies.

Authors:  Malin Wennström; Yulia Surova; Sara Hall; Christer Nilsson; Lennart Minthon; Oskar Hansson; Henrietta M Nielsen
Journal:  PLoS One       Date:  2015-08-13       Impact factor: 3.240

9.  Randomized Cross Over Study Assessing the Efficacy of Non-invasive Stimulation of the Vagus Nerve in Patients With Axial Spondyloarthritis Resistant to Biotherapies: The ESNV-SPA Study Protocol.

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Review 10.  Pituitary Adenoma and the Chemokine Network: A Systemic View.

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