Ana K Bedran-Russo1, Sachin Karol2, David H Pashley3, Grace Viana4. 1. Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Room #551, 801 South Paulina Street, Chicago, IL 60612, USA. bedran@uic.edu 2. Department of Restorative Dentistry, College of Dentistry, University of Illinois at Chicago, Room #551, 801 South Paulina Street, Chicago, IL 60612, USA. 3. Department of Oral Biology, School of Dental Medicine, Georgia Health Sciences University, Augusta, Georgia, USA. 4. Department of Orthodontics, College of Dentistry, Chicago, Illinois 60612, USA.
Abstract
PURPOSE: To assess in non-cavitated carious teeth the mechanical properties of dentin matrix by measuring its reduced modulus of elasticity and the effect of dentin biomodification strategies on three dentin matrix zones: caries-affected, apparently normal dentin below caries-affected zone and sound dentin far from carious site. METHODS: Nano-indentations were performed on dentin matrices of carious molars before and after surface modification using known cross-linking agents (glutaraldehyde, proanthocyanidins from grape seed extract and carbodiimide). RESULTS: Statistically significant differences were observed between dentin zones of demineralized dentin prior to surface biomodification (P < 0.05). Following surface modification, there were no statistically significant differences between dentin zones (P < 0.05). An average increase of 30-fold, 2-fold and 2.2-fold of the reduced modulus of elasticity was observed following treatments of the three dentin zones with proanthocyanidin, carbodiimide and glutaraldehyde, respectively.
PURPOSE: To assess in non-cavitated carious teeth the mechanical properties of dentin matrix by measuring its reduced modulus of elasticity and the effect of dentin biomodification strategies on three dentin matrix zones: caries-affected, apparently normal dentin below caries-affected zone and sound dentin far from carious site. METHODS: Nano-indentations were performed on dentin matrices of carious molars before and after surface modification using known cross-linking agents (glutaraldehyde, proanthocyanidins from grape seed extract and carbodiimide). RESULTS: Statistically significant differences were observed between dentin zones of demineralized dentin prior to surface biomodification (P < 0.05). Following surface modification, there were no statistically significant differences between dentin zones (P < 0.05). An average increase of 30-fold, 2-fold and 2.2-fold of the reduced modulus of elasticity was observed following treatments of the three dentin zones with proanthocyanidin, carbodiimide and glutaraldehyde, respectively.
Authors: Ana Karina B Bedran-Russo; David H Pashley; Kelli Agee; James L Drummond; Klaus J Miescke Journal: J Biomed Mater Res B Appl Biomater Date: 2008-08 Impact factor: 3.368
Authors: Ana Karina B Bedran-Russo; Cristina M P Vidal; Paulo H Dos Santos; Carina S Castellan Journal: J Biomed Mater Res B Appl Biomater Date: 2010-07 Impact factor: 3.368
Authors: Ana Karina B Bedran-Russo; Carina S Castellan; Mirela S Shinohara; Lina Hassan; Alberto Antunes Journal: Acta Biomater Date: 2010-12-16 Impact factor: 8.947
Authors: Ana Karina B Bedran-Russo; Patricia N R Pereira; Wagner R Duarte; James L Drummond; Mitsuo Yamauchi Journal: J Biomed Mater Res B Appl Biomater Date: 2007-01 Impact factor: 3.368
Authors: Ana K Bedran-Russo; Guido F Pauli; Shao-Nong Chen; James McAlpine; Carina S Castellan; Rasika S Phansalkar; Thaiane R Aguiar; Cristina M P Vidal; José G Napotilano; Joo-Won Nam; Ariene A Leme Journal: Dent Mater Date: 2013-12-03 Impact factor: 5.304