Hebert Alberto Vargas1, Cecilia Wassberg, Josef J Fox, Andreas Wibmer, Debra A Goldman, Deborah Kuk, Mithat Gonen, Steven M Larson, Michael J Morris, Howard I Scher, Hedvig Hricak. 1. From the Department of Radiology (H.A.V., C.W., J.J.F., A.W., D.A.G., S.M.L., H.H.), Department of Epidemiology and Biostatistics (D.K., M.G.), and Genitourinary Oncology Service, Department of Medicine (M.J.M., H.I.S.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065; and Department of Radiology, Oncology and Radiations Sciences, Section of Radiology, Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden (C.W.).
Abstract
PURPOSE: To compare the features of bone metastases at computed tomography (CT) to tracer uptake at fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and fluorine 18 16β-fluoro-5-dihydrotestosterone (FDHT) PET and to determine associations between these imaging features and overall survival in men with castration-resistant prostate cancer. MATERIALS AND METHODS: This is a retrospective study of 38 patients with castration-resistant prostate cancer. Two readers independently evaluated CT, FDG PET, and FDHT PET features of bone metastases. Associations between imaging findings and overall survival were determined by using univariate Cox proportional hazards regression. RESULTS: In 38 patients, reader 1 detected 881 lesions and reader 2 detected 867 lesions. Attenuation coefficients at CT correlated inversely with FDG (reader 1: r = -0.3007; P < .001; reader 2: r = -0.3147; P < .001) and FDHT (reader 1: r = -0.2680; P = .001; reader 2: r = -0.3656; P < .001) uptake. The number of lesions on CT scans was significantly associated with overall survival (reader 1: hazard ratio [HR], 1.025; P = .05; reader 2: HR, 1.021; P = .04). The numbers of lesions on FDG and FDHT PET scans were significantly associated with overall survival for reader 1 (HR, 1.051-1.109; P < .001) and reader 2 (HR, 1.026-1.082; P ≤ .009). Patients with higher FDHT uptake (lesion with the highest maximum standardized uptake value) had significantly shorter overall survival (reader 1: HR, 1.078; P = .02; reader 2: HR, 1.092; P = .02). FDG uptake intensity was not associated with overall survival (reader 1, P = .65; reader 2, P = .38). CONCLUSION: In patients with castration-resistant prostate cancer, numbers of bone lesions on CT, FDG PET, and FDHT PET scans and the intensity of FDHT uptake are significantly associated with overall survival. RSNA, 2013
PURPOSE: To compare the features of bone metastases at computed tomography (CT) to tracer uptake at fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and fluorine 18 16β-fluoro-5-dihydrotestosterone (FDHT) PET and to determine associations between these imaging features and overall survival in men with castration-resistant prostate cancer. MATERIALS AND METHODS: This is a retrospective study of 38 patients with castration-resistant prostate cancer. Two readers independently evaluated CT, FDG PET, and FDHT PET features of bone metastases. Associations between imaging findings and overall survival were determined by using univariate Cox proportional hazards regression. RESULTS: In 38 patients, reader 1 detected 881 lesions and reader 2 detected 867 lesions. Attenuation coefficients at CT correlated inversely with FDG (reader 1: r = -0.3007; P < .001; reader 2: r = -0.3147; P < .001) and FDHT (reader 1: r = -0.2680; P = .001; reader 2: r = -0.3656; P < .001) uptake. The number of lesions on CT scans was significantly associated with overall survival (reader 1: hazard ratio [HR], 1.025; P = .05; reader 2: HR, 1.021; P = .04). The numbers of lesions on FDG and FDHT PET scans were significantly associated with overall survival for reader 1 (HR, 1.051-1.109; P < .001) and reader 2 (HR, 1.026-1.082; P ≤ .009). Patients with higher FDHT uptake (lesion with the highest maximum standardized uptake value) had significantly shorter overall survival (reader 1: HR, 1.078; P = .02; reader 2: HR, 1.092; P = .02). FDG uptake intensity was not associated with overall survival (reader 1, P = .65; reader 2, P = .38). CONCLUSION: In patients with castration-resistant prostate cancer, numbers of bone lesions on CT, FDG PET, and FDHT PET scans and the intensity of FDHT uptake are significantly associated with overall survival. RSNA, 2013
Authors: Howard I Scher; Karim Fizazi; Fred Saad; Mary-Ellen Taplin; Cora N Sternberg; Kurt Miller; Ronald de Wit; Peter Mulders; Kim N Chi; Neal D Shore; Andrew J Armstrong; Thomas W Flaig; Aude Fléchon; Paul Mainwaring; Mark Fleming; John D Hainsworth; Mohammad Hirmand; Bryan Selby; Lynn Seely; Johann S de Bono Journal: N Engl J Med Date: 2012-08-15 Impact factor: 91.245
Authors: S D Yeh; M Imbriaco; S M Larson; D Garza; J J Zhang; H Kalaigian; R D Finn; D Reddy; S M Horowitz; S J Goldsmith; H I Scher Journal: Nucl Med Biol Date: 1996-08 Impact factor: 2.408
Authors: Steven M Larson; Michael Morris; Ilonka Gunther; Brad Beattie; John L Humm; Timothy A Akhurst; Ronald D Finn; Yusuf Erdi; Keith Pentlow; Jon Dyke; Olivia Squire; William Bornmann; Timothy McCarthy; Michael Welch; Howard Scher Journal: J Nucl Med Date: 2004-03 Impact factor: 10.057
Authors: Hebert Alberto Vargas; Gem M Kramer; Andrew M Scott; Andrew Weickhardt; Andreas A Meier; Nicole Parada; Bradley J Beattie; John L Humm; Kevin D Staton; Pat B Zanzonico; Serge K Lyashchenko; Jason S Lewis; Maqsood Yaqub; Ramon E Sosa; Alfons J van den Eertwegh; Ian D Davis; Uwe Ackermann; Kunthi Pathmaraj; Robert C Schuit; Albert D Windhorst; Sue Chua; Wolfgang A Weber; Steven M Larson; Howard I Scher; Adriaan A Lammertsma; Otto S Hoekstra; Michael J Morris Journal: J Nucl Med Date: 2018-04-06 Impact factor: 10.057
Authors: Mark Lazari; Serge K Lyashchenko; Eva M Burnazi; Jason S Lewis; R Michael van Dam; Jennifer M Murphy Journal: Appl Radiat Isot Date: 2015-05-21 Impact factor: 1.513