Literature DB >> 2447487

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

D K Luttrell1, L M Luttrell, S J Parsons.   

Abstract

C3H10T1/2 murine fibroblasts overexpressing chicken pp60c-src showed a two- to fivefold enhanced incorporation of [3H]thymidine into DNA in response to epidermal growth factor (EGF) relative to that of the parent line. No difference in growth characteristics, number and affinity of EGF receptors, or hormone potency was attributable to c-src overexpression. These results suggest that pp60c-src may interact with the mitogenic signal transduction pathway of EGF in some event distal to hormone binding.

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Year:  1988        PMID： 2447487      PMCID： PMC363160          DOI： 10.1128/mcb.8.1.497-501.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  25 in total

1.  Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

Authors:  A Golden; S P Nemeth; J S Brugge
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

2.  S phase synchrony in monolayer CHO cultures.

Authors:  J L Hamlin; A B Pardee
Journal:  Exp Cell Res       Date:  1976-07       Impact factor: 3.905

Review 3.  Early signals in the mitogenic response.

Authors:  E Rozengurt
Journal:  Science       Date:  1986-10-10       Impact factor: 47.728

4.  Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.

Authors:  M J Wakelam; S A Davies; M D Houslay; I McKay; C J Marshall; A Hall
Journal:  Nature       Date:  1986 Sep 11-17       Impact factor: 49.962

5.  Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

Authors:  C A Reznikoff; D W Brankow; C Heidelberger
Journal:  Cancer Res       Date:  1973-12       Impact factor: 12.701

6.  Potentiation of growth factor activity by exogenous c-myc expression.

Authors:  V Sorrentino; V Drozdoff; M D McKinney; L Zeitz; E Fleissner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

7.  Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product.

Authors:  M S Collett; J S Brugge; R L Erikson
Journal:  Cell       Date:  1978-12       Impact factor: 41.582

8.  The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane.

Authors:  S A Courtneidge; A D Levinson; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

9.  DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

Authors:  M Wigler; A Pellicer; S Silverstein; R Axel; G Urlaub; L Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

10.  The role of EGF receptor transmodulation in embryonal carcinoma-derived growth factor-induced mitogenesis.

Authors:  J K Heath; L Mahadevan; J G Foulkes
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
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  38 in total

1.  Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.

Authors:  W P Hausdorff; J A Pitcher; D K Luttrell; M E Linder; H Kurose; S J Parsons; M G Caron; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

2.  Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation.

Authors:  W A Bushman; L K Wilson; D K Luttrell; J S Moyers; S J Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

3.  Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene.

Authors:  W J Wasilenko; D M Payne; D L Fitzgerald; M J Weber
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

4.  Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.

Authors:  A H Bouton; S B Kanner; R R Vines; H C Wang; J B Gibbs; J T Parsons
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

5.  Inhibition of epidermal growth factor receptor biosynthesis caused by the src oncogene product, pp60v-src.

Authors:  W J Wasilenko; M Nori; N Testerman; M J Weber
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

6.  Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-Src.

Authors:  N Aziz; H Cherwinski; M McMahon
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

7.  Mechanism of biological synergy between cellular Src and epidermal growth factor receptor.

Authors:  D A Tice; J S Biscardi; A L Nickles; S J Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

8.  The sites of phosphorylation by protein kinase C and an intact SH2 domain are required for the enhanced response to beta-adrenergic agonists in cells overexpressing c-src.

Authors:  J S Moyers; A H Bouton; S J Parsons
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

9.  Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers.

Authors:  M C Maa; T H Leu; D J McCarley; R C Schatzman; S J Parsons
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-18       Impact factor: 11.205

10.  Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.

Authors:  R H Chen; J Chung; J Blenis
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272
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