Shiou-Lan Chen1, Sheng-Yu Lee2, Yun-Hsuan Chang3, Shih-Heng Chen4, Chun-Hsien Chu4, Tzu-Yun Wang5, Po-See Chen2, I-Hui Lee2, Yen-Kuang Yang2, Jau-Shyong Hong6, Ru-Band Lu7. 1. Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, National Cheng Kung University, Taiwan. Electronic address: shioulan@mail.ncku.edu.tw. 2. Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan. 3. Department of Psychiatry, National Cheng Kung University, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan. 4. Department of Psychiatry, National Cheng Kung University, Taiwan; Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA. 5. Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan. 6. Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA. 7. Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan; Institute of Behavior Medicine, National Cheng Kung University, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Taiwan. Electronic address: rblu@mail.ncku.edu.tw.
Abstract
OBJECTIVE: Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several mental disorders. METHOD: We enrolled 644 participants: 177 patients with bipolar I disorder (BP-I), 190 with bipolar II disorder (BP-II), 151 with schizophrenia, and 126 healthy controls. Their plasma BDNF levels and BDNF Val66Met single nucleotide polymorphisms (SNP) were checked before pharmacological treatment. RESULTS: Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507). Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not influence plasma BDNF levels in our participants. Plasma BDNF levels were, however, significantly negatively correlated with depression scores in patients with bipolar disorder and with negative symptoms in patients with schizophrenia. CONCLUSION: We conclude that plasma BDNF profiles in different mental disorders are not affected by BDNF Val66Met gene variants, but by the process and progression of the illness itself.
OBJECTIVE:Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNFVal66Met gene variants effect in several mental disorders. METHOD: We enrolled 644 participants: 177 patients with bipolar I disorder (BP-I), 190 with bipolar II disorder (BP-II), 151 with schizophrenia, and 126 healthy controls. Their plasma BDNF levels and BDNFVal66Met single nucleotide polymorphisms (SNP) were checked before pharmacological treatment. RESULTS: Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNFVal66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507). Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNFVal66Met SNP did not influence plasma BDNF levels in our participants. Plasma BDNF levels were, however, significantly negatively correlated with depression scores in patients with bipolar disorder and with negative symptoms in patients with schizophrenia. CONCLUSION: We conclude that plasma BDNF profiles in different mental disorders are not affected by BDNFVal66Met gene variants, but by the process and progression of the illness itself.
Authors: Antonio Terracciano; Monia Lobina; Maria Grazia Piras; Antonella Mulas; Alessandra Cannas; Osorio Meirelles; Angelina R Sutin; Alan B Zonderman; Manuela Uda; Laura Crisponi; David Schlessinger Journal: Psychosom Med Date: 2011-09-23 Impact factor: 4.312
Authors: M Takahashi; O Shirakawa; K Toyooka; N Kitamura; T Hashimoto; K Maeda; S Koizumi; K Wakabayashi; H Takahashi; T Someya; H Nawa Journal: Mol Psychiatry Date: 2000-05 Impact factor: 15.992
Authors: B S Fernandes; J Steiner; M Berk; M L Molendijk; A Gonzalez-Pinto; C W Turck; P Nardin; C-A Gonçalves Journal: Mol Psychiatry Date: 2014-09-30 Impact factor: 15.992
Authors: Anthony O Ahmed; Samantha Kramer; Naama Hofman; John Flynn; Marie Hansen; Victoria Martin; Anilkumar Pillai; Peter F Buckley Journal: Neuropsychobiology Date: 2021-03-11 Impact factor: 2.328
Authors: Brisa S Fernandes; Marc L Molendijk; Cristiano A Köhler; Jair C Soares; Cláudio Manuel G S Leite; Rodrigo Machado-Vieira; Thamara L Ribeiro; Jéssica C Silva; Paulo M G Sales; João Quevedo; Viola Oertel-Knöchel; Eduard Vieta; Ana González-Pinto; Michael Berk; André F Carvalho Journal: BMC Med Date: 2015-11-30 Impact factor: 8.775
Authors: Eva Kitzlerová; Zdeněk Fišar; Petra Lelková; Roman Jirák; Martina Zvěřová; Jana Hroudová; Ada Manukyan; Pavel Martásek; Jiří Raboch Journal: Med Sci Monit Date: 2018-04-28