OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use. RESULTS: Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression. CONCLUSIONS: Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.
OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use. RESULTS: Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression. CONCLUSIONS: Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.
Authors: A Terracciano; B Martin; D Ansari; T Tanaka; L Ferrucci; S Maudsley; M P Mattson; P T Costa Journal: Genes Brain Behav Date: 2010-03-22 Impact factor: 3.449
Authors: Pim Cuijpers; Filip Smit; Brenda W J H Penninx; Ron de Graaf; Margreet ten Have; Aartjan T F Beekman Journal: Arch Gen Psychiatry Date: 2010-10
Authors: Y Milaneschi; S Bandinelli; B W Penninx; N Vogelzangs; A M Corsi; F Lauretani; A Kisialiou; R Vazzana; A Terracciano; J M Guralnik; L Ferrucci Journal: Mol Psychiatry Date: 2010-11-02 Impact factor: 15.992
Authors: Angelina R Sutin; Lori L Beason-Held; Vonetta M Dotson; Susan M Resnick; Paul T Costa Journal: J Affect Disord Date: 2010-12 Impact factor: 4.839
Authors: Antonio Terracciano; Maria Grazia Piras; Monia Lobina; Antonella Mulas; Osorio Meirelles; Angelina R Sutin; Wayne Chan; Serena Sanna; Manuela Uda; Laura Crisponi; David Schlessinger Journal: World J Biol Psychiatry Date: 2011-11-02 Impact factor: 4.132
Authors: Antonio Terracciano; Diego Iacono; Richard J O'Brien; Juan C Troncoso; Yang An; Angelina R Sutin; Luigi Ferrucci; Alan B Zonderman; Susan M Resnick Journal: Neurobiol Aging Date: 2012-10-02 Impact factor: 4.673
Authors: Antonio Terracciano; Angelina R Sutin; Yang An; Richard J O'Brien; Luigi Ferrucci; Alan B Zonderman; Susan M Resnick Journal: Alzheimers Dement Date: 2013-05-21 Impact factor: 21.566