| Literature DB >> 17524622 |
Peter F Buckley1, Sahebarao Mahadik, Anilkumar Pillai, Alvin Terry.
Abstract
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.Entities:
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Year: 2007 PMID： 17524622 DOI： 10.1016/j.schres.2007.01.025
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939