| Literature DB >> 24462038 |
Prashant R Tembhare1, Constance M Yuan1, David Venzon2, Raul Braylan3, Neha Korde4, Elisabet Manasanch4, Diamond Zuchlinsky5, Katherine Calvo3, Roger Kurlander3, Manisha Bhutani5, Nishant Tageja5, Irina Maric3, Marcia Mulquin5, Mark Roschewski5, Mary Kwok4, David Liewehr2, Ola Landgren5, Maryalice Stetler-Stevenson6.
Abstract
Flow cytometric (FC) enumeration of abnormal plasma cells (APCs) for diagnosis and prognostication of plasma cell dyscrasias (PCD) is challenging. We studied antigen expression in normal plasma cells (NPC) (N = 34) and APC in a series of unselected PCD (N = 59). NPC subpopulations often demonstrated CD19(-), CD20(+), CD45(-) or dim and CD56(+), an immunophenotype observed in PCD. However abnormal CD81 was only observed in APCs (APC detection sensitivity 95%; specificity 100%). We evaluated differences in antigen expression patterns among MGUS (N = 14), SMM (N = 35) and MM (N = 10), finding the combination of CD45 and CD56 helpful in differentiating MGUS from SMM and MM (p = 0.0002). Published by Elsevier Ltd.Entities:
Keywords: CD81; Monoclonal gammopathy of uncertain significance; Multiple myeloma; Normal plasma cell immunophenotype; Smoldering multiple myeloma
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Year: 2013 PMID： 24462038 PMCID： PMC3947595 DOI： 10.1016/j.leukres.2013.12.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156