| Literature DB >> 24457416 |
Dominik Sturm1, Sebastian Bender1, David T W Jones2, Peter Lichter3, Jacques Grill4, Oren Becher5, Cynthia Hawkins6, Jacek Majewski7, Chris Jones8, Joseph F Costello9, Antonio Iavarone10, Kenneth Aldape11, Cameron W Brennan12, Nada Jabado7, Stefan M Pfister13.
Abstract
We have extended our understanding of the molecular biology that underlies adult glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents have remained a relatively under-investigated disease. The latest large-scale genomic and epigenomic profiling studies have yielded an unprecedented abundance of novel data and provided deeper insights into gliomagenesis across all age groups, which has highlighted key distinctions but also some commonalities. As we are on the verge of dissecting glioblastomas into meaningful biological subgroups, this Review summarizes the hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease, and examines the complex interplay between the glioblastoma genome and epigenome.Entities:
Mesh：
Year: 2014 PMID： 24457416 PMCID： PMC4003223 DOI： 10.1038/nrc3655
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716