OBJECTIVES: To study the association between the intake of fruit and vegetables and risk of esophageal adenocarcinoma (EAC), we summarized the evidence from observational studies in categorical and linear dose-response meta-analyses. METHODS: Eligible studies published up to June 2013 were retrieved via computerized searches of MEDLINE and EMBASE. Random-effects models were used to calculate summary relative risks (SRRs) and the corresponding 95% confidence intervals (CIs). Between-study heterogeneity was assessed using the Cochran's Q and I (2) statistics. RESULTS: A total of 12 studies involving 1,572 cases of EAC were included in this meta-analysis. Based on the highest versus lowest analysis, inverse associations were observed between intakes of vegetable (SRRs = 0.76, 95% CIs 0.59-0.96; P heterogeneity = 0.098, I (2) 40.4%; n = 9 studies), intakes of fruit (SRRs = 0.73, 95% CIs, 0.55-0.98; P heterogeneity = 0.03, I (2) = 52.9%; n = 9 studies), and intakes of total vegetables and fruit combined (SRRs = 0.68, 95% CI 0.49-0.93; P heterogeneity = 0.162, I (2) = 38.9%; n = 5 studies). Similar results were also observed in a linear dose-response analysis. CONCLUSION: These data support the hypothesis that intakes of vegetables and fruit may significantly reduce the risk of EAC. Further investigation with prospective designs, validated questionnaires, and good control of important confounders is warranted.
OBJECTIVES: To study the association between the intake of fruit and vegetables and risk of esophageal adenocarcinoma (EAC), we summarized the evidence from observational studies in categorical and linear dose-response meta-analyses. METHODS: Eligible studies published up to June 2013 were retrieved via computerized searches of MEDLINE and EMBASE. Random-effects models were used to calculate summary relative risks (SRRs) and the corresponding 95% confidence intervals (CIs). Between-study heterogeneity was assessed using the Cochran's Q and I (2) statistics. RESULTS: A total of 12 studies involving 1,572 cases of EAC were included in this meta-analysis. Based on the highest versus lowest analysis, inverse associations were observed between intakes of vegetable (SRRs = 0.76, 95% CIs 0.59-0.96; P heterogeneity = 0.098, I (2) 40.4%; n = 9 studies), intakes of fruit (SRRs = 0.73, 95% CIs, 0.55-0.98; P heterogeneity = 0.03, I (2) = 52.9%; n = 9 studies), and intakes of total vegetables and fruit combined (SRRs = 0.68, 95% CI 0.49-0.93; P heterogeneity = 0.162, I (2) = 38.9%; n = 5 studies). Similar results were also observed in a linear dose-response analysis. CONCLUSION: These data support the hypothesis that intakes of vegetables and fruit may significantly reduce the risk of EAC. Further investigation with prospective designs, validated questionnaires, and good control of important confounders is warranted.
Authors: Carlos A González; Guillem Pera; Antonio Agudo; H Bas Bueno-de-Mesquita; Marco Ceroti; Heiner Boeing; Mandy Schulz; Giuseppe Del Giudice; Mario Plebani; Fátima Carneiro; Franco Berrino; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Göran Hallmans; Roger Stenling; Carmen Martinez; Miren Dorronsoro; Aurelio Barricarte; Carmen Navarro; José R Quiros; Naomi Allen; Timothy J Key; Sheila Bingham; Nicholas E Day; Jakob Linseisen; Gabriele Nagel; Kim Overvad; Majken K Jensen; Anja Olsen; Anne Tjønneland; Frederike L Büchner; Petra H M Peeters; Mattijs E Numans; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Dimitrios Roukos; Antonia Trichopoulou; Theodora Psaltopoulou; Eiliv Lund; Corinne Casagrande; Nadia Slimani; Mazda Jenab; Elio Riboli Journal: Int J Cancer Date: 2006-05-15 Impact factor: 7.396
Authors: W C Willett; L Sampson; M J Stampfer; B Rosner; C Bain; J Witschi; C H Hennekens; F E Speizer Journal: Am J Epidemiol Date: 1985-07 Impact factor: 4.897
Authors: Heiko Pohl; Katharina Wrobel; Christian Bojarski; Winfried Voderholzer; Amnon Sonnenberg; Thomas Rösch; Daniel C Baumgart Journal: Am J Gastroenterol Date: 2012-12-18 Impact factor: 10.864
Authors: Stephanie M Rink; Pauline Mendola; Sunni L Mumford; Jill K Poudrier; Richard W Browne; Jean Wactawski-Wende; Neil J Perkins; Enrique F Schisterman Journal: J Acad Nutr Diet Date: 2013-03-19 Impact factor: 4.910
Authors: Lesley A Anderson; R G Peter Watson; Seamus J Murphy; Brian T Johnston; Harry Comber; Jim Mc Guigan; John V Reynolds; Liam J Murray Journal: World J Gastroenterol Date: 2007-03-14 Impact factor: 5.742
Authors: Neal D Freedman; Yikyung Park; Amy F Subar; Albert R Hollenbeck; Michael F Leitzmann; Arthur Schatzkin; Christian C Abnet Journal: Int J Cancer Date: 2007-12-15 Impact factor: 7.396
Authors: Fränzel J B van Duijnhoven; H Bas Bueno-De-Mesquita; Pietro Ferrari; Mazda Jenab; Hendriek C Boshuizen; Martine M Ros; Corinne Casagrande; Anne Tjønneland; Anja Olsen; Kim Overvad; Ole Thorlacius-Ussing; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Sophie Morois; Rudolf Kaaks; Jakob Linseisen; Heiner Boeing; Ute Nöthlings; Antonia Trichopoulou; Dimitrios Trichopoulos; Gesthimani Misirli; Domenico Palli; Sabina Sieri; Salvatore Panico; Rosario Tumino; Paolo Vineis; Petra Hm Peeters; Carla H van Gils; Marga C Ocké; Eiliv Lund; Dagrun Engeset; Guri Skeie; Laudina Rodríguez Suárez; Carlos A González; María-José Sánchez; Miren Dorronsoro; Carmen Navarro; Aurelio Barricarte; Göran Berglund; Jonas Manjer; Göran Hallmans; Richard Palmqvist; Sheila A Bingham; Kay-Tee Khaw; Timothy J Key; Naomi E Allen; Paolo Boffetta; Nadia Slimani; Sabina Rinaldi; Valentina Gallo; Teresa Norat; Elio Riboli Journal: Am J Clin Nutr Date: 2009-04-01 Impact factor: 7.045
Authors: Lucy Sun; Amy F Subar; Claire Bosire; Sanford M Dawsey; Lisa L Kahle; Thea P Zimmerman; Christian C Abnet; Ruth Heller; Barry I Graubard; Michael B Cook; Jessica L Petrick Journal: J Nutr Date: 2017-07-19 Impact factor: 4.798
Authors: J L Petrick; S E Steck; P T Bradshaw; K F Trivers; P E Abrahamson; L S Engel; K He; W-H Chow; S T Mayne; H A Risch; T L Vaughan; M D Gammon Journal: Br J Cancer Date: 2015-03-31 Impact factor: 7.640