PURPOSE: This study was conducted to assess the relationship between (11)C-choline uptake and pathologic findings obtained by combined use of magnetic resonance (MR) and positron emission tomography (PET) imaging of patients with prostate cancer. MATERIALS AND METHODS: We retrospectively evaluated 69 patients with prostate cancer who underwent (11)C-choline PET-CT and magnetic resonance imaging before radical prostatectomy. Combined MR-PET images were acquired to obtain precise anatomic information. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were compared with pathologic findings from resected specimens as the reference standard. RESULTS: The mean and standard deviation of tumor SUVmax and MTV were 3.9 ± 1.8 and 12.9 ± 16.4, respectively. Tumors with high MTV (≧8.2) were more likely to be admixed with prostatic intraepithelial neoplasia (PIN) (p < 0.0001) or hyperplasia (p < 0.0001) in the background than those without these findings. Multiple regression analysis also revealed that the presence of hyperplasia (OR; 4.25, 95% CI 1.25-14.4, p = 0.02) and PIN (OR; 9.22, 95% CI 2.60-32.7, p = 0.001) were associated with tumors with high MTV. CONCLUSION: We have demonstrated, by pathologic evaluation of patients with prostate cancer, that (11)C-choline uptake volume is greater for prostate cancer admixed with PIN and hyperplasia than that without.
PURPOSE: This study was conducted to assess the relationship between (11)C-choline uptake and pathologic findings obtained by combined use of magnetic resonance (MR) and positron emission tomography (PET) imaging of patients with prostate cancer. MATERIALS AND METHODS: We retrospectively evaluated 69 patients with prostate cancer who underwent (11)C-choline PET-CT and magnetic resonance imaging before radical prostatectomy. Combined MR-PET images were acquired to obtain precise anatomic information. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were compared with pathologic findings from resected specimens as the reference standard. RESULTS: The mean and standard deviation of tumor SUVmax and MTV were 3.9 ± 1.8 and 12.9 ± 16.4, respectively. Tumors with high MTV (≧8.2) were more likely to be admixed with prostatic intraepithelial neoplasia (PIN) (p < 0.0001) or hyperplasia (p < 0.0001) in the background than those without these findings. Multiple regression analysis also revealed that the presence of hyperplasia (OR; 4.25, 95% CI 1.25-14.4, p = 0.02) and PIN (OR; 9.22, 95% CI 2.60-32.7, p = 0.001) were associated with tumors with high MTV. CONCLUSION: We have demonstrated, by pathologic evaluation of patients with prostate cancer, that (11)C-choline uptake volume is greater for prostate cancer admixed with PIN and hyperplasia than that without.
Authors: Michael Souvatzoglou; Gregor Weirich; Sarah Schwarzenboeck; Tobias Maurer; Tibor Schuster; Ralph Alexander Bundschuh; Matthias Eiber; Ken Herrmann; Hubert Kuebler; Hans Juergen Wester; Heinz Hoefler; Juergen Gschwend; Markus Schwaiger; Uwe Treiber; Bernd Joachim Krause Journal: Clin Cancer Res Date: 2011-04-14 Impact factor: 12.531
Authors: Bernhard Scher; Michael Seitz; Wolfram Albinger; Reinhold Tiling; Michael Scherr; Hans-Christoph Becker; Michael Souvatzogluou; Franz-Josef Gildehaus; Hans-Jürgen Wester; Stefan Dresel Journal: Eur J Nucl Med Mol Imaging Date: 2006-08-24 Impact factor: 9.236
Authors: Ralph A Bundschuh; Christina M Wendl; Gregor Weirich; Mathias Eiber; Michael Souvatzoglou; Uwe Treiber; Hubert Kübler; Tobias Maurer; Jürgen E Gschwend; Hans Geinitz; Anca L Grosu; Sibylle I Ziegler; Bernd Joachim Krause Journal: Eur J Nucl Med Mol Imaging Date: 2013-02-07 Impact factor: 9.236
Authors: David Schilling; Heinz P Schlemmer; Philipp H Wagner; Patrick Böttcher; Axel S Merseburger; Philip Aschoff; Roland Bares; Christa Pfannenberg; Ute Ganswindt; Stefan Corvin; Arnulf Stenzl Journal: BJU Int Date: 2008-04-11 Impact factor: 5.588