Literature DB >> 10070713

Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging.

T Hara1, M Yuasa.   

Abstract

(beta-Hydroxyethyl)tri([11C]methyl)ammonium ([11C]choline) is a tracer very effective in imaging various human tumors using positron emission tomography (PET). We have constructed a computer-controlled [11C]choline synthetic apparatus which carries out the whole process of synthesis and product purification automatically. The setup is simple and the process quick. In 20 min, 11 GBq of [11C]choline (chloride) is obtainable from 26 GBq of [11C]CO2. The final product is a sterile and pyrogen-free [11C]choline "injection".

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Year:  1999        PMID： 10070713     DOI： 10.1016/s0969-8043(98)00097-9

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  8 in total

1.  Comparison of [(11)C]Choline ([(11)C]CHO) and [(18)F]Bombesin (BAY 86-4367) as Imaging Probes for Prostate Cancer in a PC-3 Prostate Cancer Xenograft Model.

Authors:  Sarah Marie Schwarzenböck; Philipp Schmeja; Jens Kurth; Michael Souvatzoglou; Roman Nawroth; Uwe Treiber; Guenther Kundt; Sandra Berndt; Keith Graham; Reingard Senekowitsch-Schmidtke; Markus Schwaiger; Sibylle I Ziegler; Ludger Dinkelborg; Hans-Jürgen Wester; Bernd Joachim Krause
Journal:  Mol Imaging Biol       Date:  2016-06       Impact factor: 3.488

2.  Correlation of metabolic tumor volume and 11C-choline uptake with the pathology of prostate cancer: evaluation by use of simultaneously recorded MR and PET images.

Authors:  Tomohiro Yoneyama; Ukihide Tateishi; Takashi Terauchi; Tomio Inoue
Journal:  Jpn J Radiol       Date:  2014-01-21       Impact factor: 2.374

3.  Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization.

Authors:  Dominique Slaets; Sylvie De Bruyne; Caroline Dumolyn; Lieselotte Moerman; Koen Mertens; Filip De Vos
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-06-18       Impact factor: 9.236

4.  Comparison of [¹¹C]choline ([¹¹C]CHO) and S(+)-β-methyl-[¹¹C]choline ([¹¹C]SMC) as imaging probes for prostate cancer in a PC-3 prostate cancer xenograft model.

Authors:  Sarah Marie Schwarzenböck; Jana Gertz; Michael Souvatzoglou; Jens Kurth; David Sachs; Roman Nawroth; Uwe Treiber; Tibor Schuster; Reingard Senekowitsch-Schmidtke; Markus Schwaiger; Sibylle Ilse Ziegler; Gjermund Henriksen; Hans-Jürgen Wester; Bernd Joachim Krause
Journal:  Mol Imaging Biol       Date:  2015-04       Impact factor: 3.488

5.  Comparison of cell proliferation, protein, and glucose metabolism in musculoskeletal tumors in a PET study.

Authors:  Mei Tian; Hong Zhang; Keigo Endo
Journal:  J Biomed Biotechnol       Date:  2011-06-16

6.  MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.

Authors:  J Xiong; L Wang; X-C Fei; X-F Jiang; Z Zheng; Y Zhao; C-F Wang; B Li; S-J Chen; A Janin; R P Gale; W-L Zhao
Journal:  Blood Cancer J       Date:  2017-07-07       Impact factor: 11.037

7.  Comparison of 11C-choline Positron Emission Tomography/Computed Tomography (PET/CT) and Conventional Imaging for Detection of Recurrent Prostate Cancer.

Authors:  Yusuke Kawanaka; Kazuhiro Kitajima; Shingo Yamamoto; Yukako Nakanishi; Yusuke Yamada; Takahiko Hashimoto; Toru Suzuki; Shuken Go; Akihiro Kanematsu; Michio Nojima; Keitaro Sofue; Masakatsu Trsurusaki; Yukihisa Tamaki; Rika Yoshida; Koichiro Yamakado
Journal:  Cureus       Date:  2018-07-11

8.  Synthesis, isolation and purification of [(11)C]-choline.

Authors:  Marcin Szydło; Michał Jadwiński; Agnieszka Chmura; Kamil Gorczewski; Maria Sokół
Journal:  Contemp Oncol (Pozn)       Date:  2016-08-04
  8 in total

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