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Literature DB >> 2444208

Sequence-selective binding of phleomycin to DNA.

Abstract

The binding of phleomycin and bleomycin to DNA has been investigated by studying their effects on cleavage by DNAase I and micrococcal nuclease. In the presence of cobalt, cleavage of DNA by the antibiotics is suppressed, yet they still provide protection from nuclease attack in regions surrounding the drug cleavage sites. We conclude that cleavage by phleomycin occurs at bonds around which the antibiotic is already selectively bound.

Entities: Chemical

Mesh：

Substances：

Year: 1987 PMID： 2444208 PMCID： PMC1147934 DOI： 10.1042/bj2430847

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

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Authors: R H Blum; S K Carter; K Agre
Journal: Cancer Date: 1973-04 Impact factor: 6.860

2. Chemistry of bleomycin. XXI. Metal-complex of bleomycin and its implication for the mechanism of bleomycin action.

Authors: T Takita; Y Muraoka; T Nakatani; A Fujii; Y Iitaka; H Umezawa
Journal: J Antibiot (Tokyo) Date: 1978-10 Impact factor: 2.649

3. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

Authors: A D D'Andrea; W A Haseltine
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

4. Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.

Authors: C M Low; H R Drew; M J Waring
Journal: Nucleic Acids Res Date: 1984-06-25 Impact factor: 16.971

5. The mechanism of the bleomycin-induced cleavage of DNA.

Authors: J W Lown; S K Sim
Journal: Biochem Biophys Res Commun Date: 1977-08-22 Impact factor: 3.575

6. The mechanism of sensitivity to phleomycin in growing Escherichia coli cells.

Authors: M J Sleigh; G W Grigg
Journal: Biochem J Date: 1976-04-01 Impact factor: 3.857

7. Oxygenated iron bleomycin. A short-lived intermediate in the reaction of ferrous bleomycin with O2.

Authors: R M Burger; S B Horwitz; J Peisach; J B Wittenberg
Journal: J Biol Chem Date: 1979-12-25 Impact factor: 5.157

8. The mechanism of DNA breakage by phleomycin in vitro.

Authors: M J Sleigh
Journal: Nucleic Acids Res Date: 1976-04 Impact factor: 16.971

9. Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin.

Authors: R M Burger; A R Berkowitz; J Peisach; S B Horwitz
Journal: J Biol Chem Date: 1980-12-25 Impact factor: 5.157

10. Interaction of bleomycin with DNA.

Authors: M Takeshita; A P Grollman; E Ohtsubo; H Ohtsubo
Journal: Proc Natl Acad Sci U S A Date: 1978-12 Impact factor: 11.205

7 in total

1. DNA structure influences sequence specific cleavage by bleomycin.

Authors: K P Nightingale; K R Fox
Journal: Nucleic Acids Res Date: 1993-06-11 Impact factor: 16.971

2. Interaction of bleomycin with a bent DNA fragment.

Authors: K P Nightingale; K R Fox
Journal: Biochem J Date: 1992-06-15 Impact factor: 3.857

3. Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin.

Authors: K R Fox; G W Grigg
Journal: Nucleic Acids Res Date: 1988-03-25 Impact factor: 16.971

4. Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.

Authors: Won Hee Jung; Anita Sham; Rick White; James W Kronstad
Journal: PLoS Biol Date: 2006-11 Impact factor: 8.029

5. A genomic screen revealing the importance of vesicular trafficking pathways in genome maintenance and protection against genotoxic stress in diploid Saccharomyces cerevisiae cells.

Authors: Kamil Krol; Izabela Brozda; Marek Skoneczny; Maria Bretner; Maria Bretne; Adrianna Skoneczna
Journal: PLoS One Date: 2015-03-10 Impact factor: 3.240

6. DNA methylation changes following DNA damage in prostate cancer cells.

Authors: Laura P Sutton; Sarah A Jeffreys; Jessica L Phillips; Phillippa C Taberlay; Adele F Holloway; Mark Ambrose; Ji-Hoon E Joo; Arabella Young; Rachael Berry; Marketa Skala; Kate H Brettingham-Moore
Journal: Epigenetics Date: 2019-06-17 Impact factor: 4.528

7. Mechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavage.

Authors: Jingyang Chen; Manas K Ghorai; Grace Kenney; JoAnne Stubbe
Journal: Nucleic Acids Res Date: 2008-05-20 Impact factor: 16.971

7 in total