Literature DB >> 2442886

Desmin: its value as a marker of muscle derived tumours using a commercial antibody.

M Leader, M Collins, J Patel, K Henry.   

Abstract

This study examined the staining reactions of a commercially available anti desmin antibody in 192 soft tissue sarcomas, 30 carcinomas and 22 malignant melanomas. Only 63% of rhabdomyosarcomas and 50% of leiomyosarcomas showed a positive reaction. Three non muscle sarcomas also reacted with the antibody. No positivity was seen amongst the carcinomas or the melanomas. These results do not compare favourably with the documented results of non commercial desmin antibodies in the literature. The most likely cause of the discrepancy in the varying results is the differing source of the antibody.

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Year:  1987        PMID： 2442886     DOI： 10.1007/bf00713379

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  18 in total

1.  The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique.

Authors:  B L Mepham; W Frater; B S Mitchell
Journal:  Histochem J       Date:  1979-05

2.  Trypsin digestion in immunoperoxidase staining.

Authors:  N W Hautzer; J F Wittkuhn; W T Mccaughey
Journal:  J Histochem Cytochem       Date:  1980-01       Impact factor: 2.479

3.  Antibodies to intermediate filament proteins. The differential diagnosis of cutaneous tumors.

Authors:  M Miettinen; V P Lehto; I Virtanen
Journal:  Arch Dermatol       Date:  1985-06

4.  Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin.

Authors:  G Gabbiani; E Schmid; S Winter; C Chaponnier; C de Ckhastonay; J Vandekerckhove; K Weber; W W Franke
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

5.  Alveolar rhabdomyosarcoma. Demonstration of the muscle type of intermediate filament protein, desmin, as a diagnostic aid.

Authors:  M Miettinen; V P Lehto; R A Badley; I Virtanen
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

6.  Aortic smooth muscle cells contain vimentin instead of desmin.

Authors:  E D Frank; L Warren
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

7.  Desmin is a specific marker for rhabdomyosarcomas of human and rat origin.

Authors:  M Altmannsberger; K Weber; R Droste; M Osborn
Journal:  Am J Pathol       Date:  1985-01       Impact factor: 4.307

8.  An analysis of the sensitivity and specificity of the cytokeratin marker CAM 5.2 for epithelial tumours. Results of a study of 203 sarcomas, 50 carcinomas and 28 malignant melanomas.

Authors:  M Leader; J Patel; C Makin; K Henry
Journal:  Histopathology       Date:  1986-12       Impact factor: 5.087

9.  Vimentin: an evaluation of its role as a tumour marker.

Authors:  M Leader; M Collins; J Patel; K Henry
Journal:  Histopathology       Date:  1987-01       Impact factor: 5.087

10.  Redistribution of intermediate filament subunits during skeletal myogenesis and maturation in vitro.

Authors:  G S Bennett; S A Fellini; Y Toyama; H Holtzer
Journal:  J Cell Biol       Date:  1979-08       Impact factor: 10.539
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  9 in total

1.  Cytoskeletal characteristics of myofibroblasts in benign neoplastic and reactive fibroblastic lesions.

Authors:  T Hasegawa; T Hirose; E Kudo; J Abe; K Hizawa
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

2.  Primary breast sarcoma: a review of 33 cases with immunohistochemistry and prognostic factors.

Authors:  P Terrier; M J Terrier-Lacombe; H Mouriesse; S Friedman; M Spielmann; G Contesso
Journal:  Breast Cancer Res Treat       Date:  1989-01       Impact factor: 4.872

3.  Aberrant intermediate filament and synaptophysin expression is a frequent event in malignant melanoma: an immunohistochemical study of 73 cases.

Authors:  Ryan C Romano; Jodi M Carter; Andrew L Folpe
Journal:  Mod Pathol       Date:  2015-05-29       Impact factor: 7.842

4.  Desmin expression in spindle cell lipomas: a potential diagnostic pitfall.

Authors:  Juan C Tardío; José A Aramburu; Carlos Santonja
Journal:  Virchows Arch       Date:  2004-08-20       Impact factor: 4.064

5.  Morphological heterogeneity and phenotypical instability versus metastatic stability in the murine tumor model ER 15-P.

Authors:  G Edel; A Roessner; B Deneke; B Wörmann
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

Review 6.  KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.

Authors:  M Cassidy; B Loftus; A Whelan; B Sabt; D Hickey; K Henry; M Leader
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

7.  Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood.

Authors:  N P Wang; J Marx; M A McNutt; J C Rutledge; A M Gown
Journal:  Am J Pathol       Date:  1995-12       Impact factor: 4.307

8.  Myoglobin: an evaluation of its role as a marker of rhabdomyosarcomas.

Authors:  M Leader; J Patel; M Collins; K Henry
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640

Review 9.  [Leiomyosarcoma of the tongue: about a case].

Authors:  Lahcen El Jahd; Ismail Barhmi; Nabil Tazi; Sami Rouadi; Reda Abada; Mohammed Roubal; Abdelaziz Janah; Mohammed Mahtar
Journal:  Pan Afr Med J       Date:  2015-09-04
  9 in total

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