Literature DB >> 24421322

PIAS adds methyl-bias to HSC-differentiation.

Saghi Ghaffari1.   

Abstract

Epigenetic modifications of stem cell genome including DNA methylation and histone modifications are critical for the regulation of stem cell gene expression and maintenance of stem cell pool and their differentiation. Although the importance of epigenetic modifications specifically DNA methylation to adult hematopoietic stem cells (HSC) has been established, the identity of specific modulators and precise mechanism of integration of methylation events remain to be uncovered. In this issue, Shuai and colleagues identify the SUMO E3 ligase PIAS1 (protein inhibitor of activated STAT1) as a key regulator of DNA methylation of HSC required for their maintenance and lineage commitment (Liu et al, 2014).

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Year:  2014        PMID： 24421322      PMCID： PMC3989602          DOI： 10.1002/embj.201387332

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  12 in total

Review 1.  DNA methylation: roles in mammalian development.

Authors:  Zachary D Smith; Alexander Meissner
Journal:  Nat Rev Genet       Date:  2013-02-12       Impact factor: 53.242

2.  PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells.

Authors:  Bin Liu; Kathleen M Yee; Samuel Tahk; Ryan Mackie; Cary Hsu; Ke Shuai
Journal:  EMBO J       Date:  2013-12-15       Impact factor: 11.598

3.  Dnmt3a is essential for hematopoietic stem cell differentiation.

Authors:  Grant A Challen; Deqiang Sun; Mira Jeong; Min Luo; Jaroslav Jelinek; Jonathan S Berg; Christoph Bock; Aparna Vasanthakumar; Hongcang Gu; Yuanxin Xi; Shoudan Liang; Yue Lu; Gretchen J Darlington; Alexander Meissner; Jean-Pierre J Issa; Lucy A Godley; Wei Li; Margaret A Goodell
Journal:  Nat Genet       Date:  2011-12-04       Impact factor: 38.330

4.  The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.

Authors:  Bin Liu; Samuel Tahk; Kathleen M Yee; Guoping Fan; Ke Shuai
Journal:  Science       Date:  2010-10-22       Impact factor: 47.728

5.  DNMT3A mutations in acute myeloid leukemia.

Authors:  Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal:  N Engl J Med       Date:  2010-11-10       Impact factor: 91.245

6.  Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

Authors:  Xiao-Jing Yan; Jie Xu; Zhao-Hui Gu; Chun-Ming Pan; Gang Lu; Yang Shen; Jing-Yi Shi; Yong-Mei Zhu; Lin Tang; Xiao-Wei Zhang; Wen-Xue Liang; Jian-Qing Mi; Huai-Dong Song; Ke-Qin Li; Zhu Chen; Sai-Juan Chen
Journal:  Nat Genet       Date:  2011-03-13       Impact factor: 38.330

Review 7.  Rethinking how DNA methylation patterns are maintained.

Authors:  Peter A Jones; Gangning Liang
Journal:  Nat Rev Genet       Date:  2009-09-30       Impact factor: 53.242

8.  DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.

Authors:  Jennifer J Trowbridge; Jonathan W Snow; Jonghwan Kim; Stuart H Orkin
Journal:  Cell Stem Cell       Date:  2009-10-02       Impact factor: 24.633

9.  Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

Authors:  Britta Will; Thomas O Vogler; Boris Bartholdy; Francine Garrett-Bakelman; Jillian Mayer; Laura Barreyro; Ashley Pandolfi; Tihomira I Todorova; Ujunwa C Okoye-Okafor; Robert F Stanley; Tushar D Bhagat; Amit Verma; Maria E Figueroa; Ari Melnick; Michael Roth; Ulrich Steidl
Journal:  Nat Immunol       Date:  2013-04-07       Impact factor: 25.606

10.  De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.

Authors:  Yuko Tadokoro; Hideo Ema; Masaki Okano; En Li; Hiromitsu Nakauchi
Journal:  J Exp Med       Date:  2007-04-09       Impact factor: 14.307
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