| Literature DB >> 24418568 |
Chengli Shen1, Phalguni Gupta2, Xiaochuan Xu1, Anwesha Sanyal1, Charles Rinaldo1, Eric Seaberg3, Joseph B Margolick3, Otoniel Martinez-Maza4, Yue Chen5.
Abstract
HIV/HCV co-infection provides a model to determine the role of immunity on HCV transmission and evolution. In this study HCV transmission and evolution were evaluated in 6 HCV seroconverters in HIV-infected subjects with a wide range of CD4 cell count. The HCV envelope E1/E2 sequences were analyzed for transmission bottleneck, viral diversity/divergence, immune pressure, and mutations of HLA class I/II restricted epitopes. HCV infection started with transmission bottleneck in all HIV-infected individuals. During the 1.0-2.0 years of infection there was a shift of viral quasispecies in majority of the subjects from one to next visit. However, HCV diversity, divergence, mutations in HLA class I/II restricted and virus neutralizing epitopes were similar in all subjects regardless of CD4 cell count at the time of HCV infection. Our results suggest that HCV transmission and evolution in HIV-infected subjects may not be influenced by host CD4 cell count at the time of infection.Entities:
Keywords: CD4 cell count; Evolution; HCV seroconverter; HIV; Transmission
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Year: 2013 PMID： 24418568 PMCID： PMC4337793 DOI： 10.1016/j.virol.2013.11.001
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616