Literature DB >> 24410190

Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer.

Chen-Sheng Li1, Shu-Xiang Zhang, Hong-Jun Liu, Yu-Long Shi, Le-Ping Li, Xiao-Bo Guo, Zhen-Hai Zhang.   

Abstract

The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.

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Year:  2014        PMID： 24410190     DOI： 10.3109/1354750X.2013.876555

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  7 in total

Review 1.  FGFR4: A promising therapeutic target for breast cancer and other solid tumors.

Authors:  Kevin M Levine; Kai Ding; Lyuqin Chen; Steffi Oesterreich
Journal:  Pharmacol Ther       Date:  2020-05-31       Impact factor: 12.310

2.  Fibroblast growth factor receptor 4 protein expression and clinicopathological features in gastric cancer.

Authors:  Hao Chen; Dan-Ping Shen; Zi-Zhen Zhang; Jia-Hua Liu; Yan-Ying Shen; Xing-Zhi Ni
Journal:  World J Gastroenterol       Date:  2015-02-14       Impact factor: 5.742

3.  Expression of fibroblast growth factor receptor 4 and clinical response to lenvatinib in patients with anaplastic thyroid carcinoma: a pilot study.

Authors:  Haruhiko Yamazaki; Tomoyuki Yokose; Hiroyuki Hayashi; Hiroyuki Iwasaki; Sachie Osanai; Nobuyasu Suganuma; Hirotaka Nakayama; Katsuhiko Masudo; Yasushi Rino; Munetaka Masuda
Journal:  Eur J Clin Pharmacol       Date:  2020-02-07       Impact factor: 2.953

4.  Maelstrom promotes tumor metastasis through regulation of FGFR4 and epithelial-mesenchymal transition in epithelial ovarian cancer.

Authors:  Wei-Peng He; Gui-Ping Yang; Zun-Xian Yang; Hong-Wei Shen; Ze-Shan You; Guo-Fen Yang
Journal:  J Ovarian Res       Date:  2022-05-06       Impact factor: 4.234

5.  FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.

Authors:  Yu-Pan Bai; Kun Shang; Huan Chen; Fei Ding; Zhen Wang; Chen Liang; Ye Xu; Meng-Hong Sun; Ying-Yi Li
Journal:  Cancer Sci       Date:  2015-09-04       Impact factor: 6.716

6.  Different clinical significance of FGFR1-4 expression between diffuse-type and intestinal-type gastric cancer.

Authors:  Mikito Inokuchi; Hideaki Murase; Sho Otsuki; Tatsuyuki Kawano; Kazuyuki Kojima
Journal:  World J Surg Oncol       Date:  2017-01-05       Impact factor: 2.754

7.  Fibroblast growth factor receptor 4 as a prognostic indicator in triple-negative breast cancer.

Authors:  Wei Wei; Shiyu Cao; Jing Liu; Yuhang Wang; Quanfu Song; Leha A; Shanshan Sun; Xianyu Zhang; Xiaoshuan Liang; Yongdong Jiang
Journal:  Transl Cancer Res       Date:  2020-11       Impact factor: 1.241
  7 in total

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