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Literature DB >> 24405851

Small-molecule based musculoskeletal regenerative engineering.

Kevin W-H Lo¹, Tao Jiang², Keith A Gagnon³, Clarke Nelson⁴, Cato T Laurencin⁵.

Abstract

Clinicians and scientists working in the field of regenerative engineering are actively investigating a wide range of methods to promote musculoskeletal tissue regeneration. Small-molecule-mediated tissue regeneration is emerging as a promising strategy for regenerating various musculoskeletal tissues and a large number of small-molecule compounds have been recently discovered as potential bioactive molecules for musculoskeletal tissue repair and regeneration. In this review, we summarize the recent literature encompassing the past 4 years in the area of small bioactive molecules for promoting repair and regeneration of various musculoskeletal tissues including bone, muscle, cartilage, tendon, and nerve.

Entities: CellLine Chemical Disease Gene Species

Keywords: musculoskeletal tissue; regenerative engineering; small molecules; tissue regeneration

Mesh：

Year: 2014 PMID： 24405851 PMCID： PMC3992320 DOI： 10.1016/j.tibtech.2013.12.002

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

76 in total

1. Controlled growth factor delivery for tissue engineering.

Authors: Prakriti Tayalia; David J Mooney
Journal: Adv Mater Date: 2009-09-04 Impact factor: 30.849

2. db-Cyclic adenosine monophosphate promotes axon regeneration and motor function recovery in cerebral ischemia-reperfusion rats.

Authors: Lingchuan Niu; Jia Zhou; Ying Huang; Yan Chen; Changqing Li
Journal: Neurol India Date: 2010 Mar-Apr Impact factor: 2.117

3. Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Authors: William A Weiss; Stephen S Taylor; Kevan M Shokat
Journal: Nat Chem Biol Date: 2007-12 Impact factor: 15.040

4. Local administration of alendronate reduced peri-tunnel bone loss and promoted graft-bone tunnel healing with minimal systemic effect on bone in contralateral knee.

Authors: Pauline Po Yee Lui; Yuk Wa Lee; Tsui Yu Mok; Yau Chuk Cheuk
Journal: J Orthop Res Date: 2013-07-22 Impact factor: 3.494

5. Strontium ranelate increases cartilage matrix formation.

Authors: Y Henrotin; A Labasse; S X Zheng; P Galais; Y Tsouderos; J M Crielaard; J Y Reginster
Journal: J Bone Miner Res Date: 2001-02 Impact factor: 6.741

6. Bone morphogenetic protein binding peptide mechanism and enhancement of osteogenic protein-1 induced bone healing.

Authors: Cyrus E Taghavi; Kwang-Bok Lee; Wubing He; Gun Keorochana; Samuel S Murray; Elsa J Brochmann; Hasan Uludag; Keyvan Behnam; Jeffrey C Wang
Journal: Spine (Phila Pa 1976) Date: 2010-11-01 Impact factor: 3.468

Review 7. Studies of bone morphogenetic protein-based surgical repair.

Authors: Kevin W-H Lo; Bret D Ulery; Keshia M Ashe; Cato T Laurencin
Journal: Adv Drug Deliv Rev Date: 2012-04-02 Impact factor: 15.470

8. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads.

Authors: Kerrie L Taylor; Nicola J Grant; Nicholas D Temperley; E Elizabeth Patton
Journal: Cell Commun Signal Date: 2010-06-12 Impact factor: 5.712

Review 9. Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature.

Authors: Da-Woon Jung; Darren R Williams
Journal: ACS Chem Biol Date: 2012-10-17 Impact factor: 5.100

10. Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model.

Authors: De-gang Yu; Hui-feng Ding; Yuan-qing Mao; Ming Liu; Bo Yu; Xin Zhao; Xiao-qing Wang; Yang Li; Guang-wang Liu; Shao-bo Nie; Shen Liu; Zhen-an Zhu
Journal: Acta Pharmacol Sin Date: 2013-01-21 Impact factor: 6.150

18 in total

1. Kartogenin-loaded coaxial PGS/PCL aligned nanofibers for cartilage tissue engineering.

Authors: João C Silva; Ranodhi N Udangawa; Jianle Chen; Chiara D Mancinelli; Fábio F F Garrudo; Paiyz E Mikael; Joaquim M S Cabral; Frederico Castelo Ferreira; Robert J Linhardt
Journal: Mater Sci Eng C Mater Biol Appl Date: 2019-10-08 Impact factor: 7.328

2. Combining Smoothened Agonist and NEL-Like Protein-1 Enhances Bone Healing.

Authors: Soonchul Lee; Chenchao Wang; Hsin Chuan Pan; Swati Shrestha; Carolyn Meyers; Catherine Ding; Jia Shen; Eric Chen; Min Lee; Chia Soo; Kang Ting; Aaron W James
Journal: Plast Reconstr Surg Date: 2017-06 Impact factor: 4.730

Review 3. Biomaterials for Bone Regenerative Engineering.

Authors: Xiaohua Yu; Xiaoyan Tang; Shalini V Gohil; Cato T Laurencin
Journal: Adv Healthc Mater Date: 2015-04-07 Impact factor: 9.933

4. Physical Stimulations for Bone and Cartilage Regeneration.

Authors: Xiaobin Huang; Ritopa Das; Avi Patel; Thanh Duc Nguyen
Journal: Regen Eng Transl Med Date: 2018-06-25

Review 5. Emergence of the Stem Cell Secretome in Regenerative Engineering.

Authors: Leila Daneshmandi; Shiv Shah; Tahereh Jafari; Maumita Bhattacharjee; Deandra Momah; Nikoo Saveh-Shemshaki; Kevin W-H Lo; Cato T Laurencin
Journal: Trends Biotechnol Date: 2020-07-01 Impact factor: 19.536

Review 6. Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications.

Authors: Cato T Laurencin; Keshia M Ashe; Nicole Henry; Ho Man Kan; Kevin W-H Lo
Journal: Drug Discov Today Date: 2014-02-06 Impact factor: 7.851