Literature DB >> 24399479

GM3 and diabetes.

Jin-ichi Inokuchi1.   

Abstract

We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".

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Year:  2014        PMID： 24399479     DOI： 10.1007/s10719-013-9516-4

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  26 in total

1.  Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.

Authors:  J de Graaf; H L Hak-Lemmers; M P Hectors; P N Demacker; J C Hendriks; A F Stalenhoef
Journal:  Arterioscler Thromb       Date:  1991 Mar-Apr

2.  Incorporation and localisation of ganglioside GM3 in human intimal atherosclerotic lesions.

Authors:  Y V Bobryshev; R S Lord; N K Golovanova; E V Gracheva; N D Zvezdina; V L Sadovskaya; N V Prokazova
Journal:  Biochim Biophys Acta       Date:  1997-10-24

3.  Phenotype determination of anti-GM3 positive cells in atherosclerotic lesions of the human aorta. Hypothetical role of ganglioside GM3 in foam cell formation.

Authors:  Y V Bobryshev; R S Lord; N K Golovanova; E V Gracheva; N D Zvezdina; N V Prokazova
Journal:  Biochim Biophys Acta       Date:  2001-02-14

Review 4.  Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains.

Authors:  Adriane Regina Todeschini; Sen-itiroh Hakomori
Journal:  Biochim Biophys Acta       Date:  2007-10-22

5.  Ceramides and glucosylceramides are independent antagonists of insulin signaling.

Authors:  Jose A Chavez; M Mobin Siddique; Siew Tein Wang; Jianhong Ching; James A Shayman; Scott A Summers
Journal:  J Biol Chem       Date:  2013-11-08       Impact factor: 5.157

6.  Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.

Authors:  Joo-Won Park; Woo-Jae Park; Yael Kuperman; Sigalit Boura-Halfon; Yael Pewzner-Jung; Anthony H Futerman
Journal:  Hepatology       Date:  2012-12-06       Impact factor: 17.425

7.  Low-density lipoprotein subclass patterns and risk of myocardial infarction.

Authors:  M A Austin; J L Breslow; C H Hennekens; J E Buring; W C Willett; R M Krauss
Journal:  JAMA       Date:  1988-10-07       Impact factor: 56.272

8.  A comparison of the ganglioside distributions of fat tissues in various animals by two-dimensional thin layer chromatography.

Authors:  M Ohashi
Journal:  Lipids       Date:  1979-01       Impact factor: 1.880

9.  Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

Authors:  G S Hotamisligil; N S Shargill; B M Spiegelman
Journal:  Science       Date:  1993-01-01       Impact factor: 47.728

Review 10.  Physiopathological function of hematoside (GM3 ganglioside).

Authors:  Jin-ichi Inokuchi
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2011       Impact factor: 3.493
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  18 in total

1.  Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.

Authors:  Shinji Go; Shiori Go; Lucas Veillon; Maria Grazia Ciampa; Laura Mauri; Chihiro Sato; Ken Kitajima; Alessandro Prinetti; Sandro Sonnino; Jin-Ichi Inokuchi
Journal:  J Biol Chem       Date:  2017-03-08       Impact factor: 5.157

2.  Quantitative GSL-glycome analysis of human whole serum based on an EGCase digestion and glycoblotting method.

Authors:  Jun-ichi Furukawa; Shota Sakai; Ikuko Yokota; Kazue Okada; Hisatoshi Hanamatsu; Takashi Kobayashi; Yasunobu Yoshida; Kenichi Higashino; Tomohiro Tamura; Yasuyuki Igarashi; Yasuro Shinohara
Journal:  J Lipid Res       Date:  2015-09-28       Impact factor: 5.922

3.  Ganglioside deficiency in hypothalamic POMC neurons promotes body weight gain.

Authors:  V Dieterle; S Herzer; H-J Gröne; R Jennemann; V Nordström
Journal:  Int J Obes (Lond)       Date:  2019-06-05       Impact factor: 5.095

4.  Metabolic features of chronic fatigue syndrome.

Authors:  Robert K Naviaux; Jane C Naviaux; Kefeng Li; A Taylor Bright; William A Alaynick; Lin Wang; Asha Baxter; Neil Nathan; Wayne Anderson; Eric Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-29       Impact factor: 11.205

5.  Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.

Authors:  Pablo Hh Lopez; Susan Aja; Kazuhiro Aoki; Marcus M Seldin; Xia Lei; Gabriele V Ronnett; G William Wong; Ronald L Schnaar
Journal:  Glycobiology       Date:  2016-09-28       Impact factor: 4.313

Review 6.  Insulin Receptor Isoforms in Physiology and Disease: An Updated View.

Authors:  Antonino Belfiore; Roberta Malaguarnera; Veronica Vella; Michael C Lawrence; Laura Sciacca; Francesco Frasca; Andrea Morrione; Riccardo Vigneri
Journal:  Endocr Rev       Date:  2017-10-01       Impact factor: 19.871

7.  Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.

Authors:  Chin Fen Teo; Enas Gad El-Karim; Lance Wells
Journal:  Glycobiology       Date:  2016-04-12       Impact factor: 4.313

8.  Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome.

Authors:  Lucas Veillon; Shinji Go; Wakana Matsuyama; Akemi Suzuki; Mika Nagasaki; Yutaka Yatomi; Jin-Ichi Inokuchi
Journal:  PLoS One       Date:  2015-06-23       Impact factor: 3.240

Review 9.  Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function.

Authors:  Maria Laura Allende; Richard L Proia
Journal:  Glycoconj J       Date:  2014-10-29       Impact factor: 2.916

10.  Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation.

Authors:  Maria L Allende; Emily K Cook; Bridget C Larman; Adrienne Nugent; Jacqueline M Brady; Diane Golebiowski; Miguel Sena-Esteves; Cynthia J Tifft; Richard L Proia
Journal:  J Lipid Res       Date:  2018-01-22       Impact factor: 5.922
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