Literature DB >> 24395233

Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia.

Viola C Scoffone1, Francesca Spadaro, Claudia Udine, Vadim Makarov, Marco Fondi, Renato Fani, Edda De Rossi, Giovanna Riccardi, Silvia Buroni.   

Abstract

The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance.

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Year:  2014        PMID： 24395233      PMCID： PMC4023784          DOI： 10.1128/AAC.02438-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  New 2-thiopyridines as potential candidates for killing both actively growing and dormant Mycobacterium tuberculosis cells.

Authors:  Elena Salina; Olga Ryabova; Arseny Kaprelyants; Vadim Makarov
Journal:  Antimicrob Agents Chemother       Date:  2013-10-14       Impact factor: 5.191

Review 2.  The changing microbial epidemiology in cystic fibrosis.

Authors:  John J Lipuma
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

3.  Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa.

Authors:  O Lomovskaya; A Lee; K Hoshino; H Ishida; A Mistry; M S Warren; E Boyer; S Chamberland; V J Lee
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

4.  Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia.

Authors:  S D Aaron; W Ferris; D A Henry; D P Speert; N E Macdonald
Journal:  Am J Respir Crit Care Med       Date:  2000-04       Impact factor: 21.405

5.  Burkholderia cenocepacia and Burkholderia multivorans: influence on survival in cystic fibrosis.

Authors:  A M Jones; M E Dodd; J R W Govan; V Barcus; C J Doherty; J Morris; A K Webb
Journal:  Thorax       Date:  2004-11       Impact factor: 9.139

Review 6.  Pathophysiology and management of pulmonary infections in cystic fibrosis.

Authors:  Ronald L Gibson; Jane L Burns; Bonnie W Ramsey
Journal:  Am J Respir Crit Care Med       Date:  2003-10-15       Impact factor: 21.405

7.  A plasmid which can be transferred between Escherichia coli and Pasteurella haemolytica by electroporation and conjugation.

Authors:  F F Craig; J G Coote; R Parton; J H Freer; N J Gilmour
Journal:  J Gen Microbiol       Date:  1989-11

8.  BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.

Authors:  Y Y Chan; T M C Tan; Y M Ong; K L Chua
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

9.  Deciphering the role of RND efflux transporters in Burkholderia cenocepacia.

Authors:  Silvia Bazzini; Claudia Udine; Andrea Sass; Maria Rosalia Pasca; Francesca Longo; Giovanni Emiliani; Marco Fondi; Elena Perrin; Francesca Decorosi; Carlo Viti; Luciana Giovannetti; Livia Leoni; Renato Fani; Giovanna Riccardi; Eshwar Mahenthiralingam; Silvia Buroni
Journal:  PLoS One       Date:  2011-04-19       Impact factor: 3.240

10.  Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.

Authors:  Silvia Buroni; Maria R Pasca; Ronald S Flannagan; Silvia Bazzini; Anna Milano; Iris Bertani; Vittorio Venturi; Miguel A Valvano; Giovanna Riccardi
Journal:  BMC Microbiol       Date:  2009-09-17       Impact factor: 3.605
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  8 in total

1.  Differential roles of RND efflux pumps in antimicrobial drug resistance of sessile and planktonic Burkholderia cenocepacia cells.

Authors:  Silvia Buroni; Nele Matthijs; Francesca Spadaro; Heleen Van Acker; Viola C Scoffone; Maria Rosalia Pasca; Giovanna Riccardi; Tom Coenye
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

2.  Efflux pump-mediated drug resistance in Burkholderia.

Authors:  Nicole L Podnecky; Katherine A Rhodes; Herbert P Schweizer
Journal:  Front Microbiol       Date:  2015-04-14       Impact factor: 5.640

3.  Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections.

Authors:  Aygun Israyilova; Silvia Buroni; Federico Forneris; Viola Camilla Scoffone; Namiq Q Shixaliyev; Giovanna Riccardi; Laurent Roberto Chiarelli
Journal:  PLoS One       Date:  2016-11-29       Impact factor: 3.240

4.  Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.

Authors:  Elena Perrin; Marco Fondi; Emanuele Bosi; Alessio Mengoni; Silvia Buroni; Viola Camilla Scoffone; Miguel Valvano; Renato Fani
Journal:  BMC Genomics       Date:  2017-10-30       Impact factor: 3.969

Review 5.  Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches.

Authors:  Viola C Scoffone; Laurent R Chiarelli; Gabriele Trespidi; Massimo Mentasti; Giovanna Riccardi; Silvia Buroni
Journal:  Front Microbiol       Date:  2017-08-22       Impact factor: 5.640

6.  Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia.

Authors:  Laurent R Chiarelli; Viola Camilla Scoffone; Gabriele Trespidi; Giulia Barbieri; Olga Riabova; Natalia Monakhova; Alessio Porta; Giulia Manina; Giovanna Riccardi; Vadim Makarov; Silvia Buroni
Journal:  Front Microbiol       Date:  2020-04-07       Impact factor: 5.640

7.  Molecular Characterization of the Burkholderia cenocepacia dcw Operon and FtsZ Interactors as New Targets for Novel Antimicrobial Design.

Authors:  Gabriele Trespidi; Viola Camilla Scoffone; Giulia Barbieri; Giovanna Riccardi; Edda De Rossi; Silvia Buroni
Journal:  Antibiotics (Basel)       Date:  2020-11-24

8.  Efflux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia.

Authors:  Viola C Scoffone; Olga Ryabova; Vadim Makarov; Paolo Iadarola; Marco Fumagalli; Marco Fondi; Renato Fani; Edda De Rossi; Giovanna Riccardi; Silvia Buroni
Journal:  Front Microbiol       Date:  2015-08-05       Impact factor: 5.640
  8 in total

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