Literature DB >> 24392202

Sapphire ball lensed fiber probe for common-path optical coherence tomography in ocular imaging and sensing.

Mingtao Zhao1, Yong Huang1, Jin U Kang1.   

Abstract

We describe a novel common-path optical coherence tomography (CP-OCT) fiber probe design using a sapphire ball lens for cross-sectional imaging and sensing in retina vitrectomy surgery. Single mode Gaussian beam (TEM00) simulation was used to optimize lateral resolution and working distance (WD) of the common-path probe. A theoretical sensitivity model for CP-OCT was prosed to assess its optimal performance based an unbalanced photodetector configuration. Two probe designs with working distances (WD) 415μm and 1221μm and lateral resolution 11μm and 18μm, respectively were implemented with sensitivity up to 88dB. The designs are also fully compatible with conventional Michelson interferometer based OCT configurations. The reference plane of the probe, located at the distal beam exit interface of the single mode fiber (SMF), was encased within a 25-gauge hypodermic needle by the sapphire ball lens facilitates its applications in bloody and harsh environments. The performances of the fiber probe with 11μm of lateral resolution and 19μm of axial resolution were demonstrated by cross-sectional imaging of a cow cornea and retina in vitro with a 1310nm swept source OCT system. This probe was also attached to a piezoelectric motor for active compensation of physiological tremor for handheld retinal surgical tools.

Entities:  

Keywords:  fiber probe; optical coherence tomography; retina imaging

Year:  2013        PMID: 24392202      PMCID: PMC3877324          DOI: 10.1117/12.2005099

Source DB:  PubMed          Journal:  Proc SPIE Int Soc Opt Eng        ISSN: 0277-786X


  16 in total

1.  Aberration characterization for the optimal design of high-resolution endoscopic optical coherence tomography catheters.

Authors:  Wladimir A Benalcazar; Woonggyu Jung; Stephen A Boppart
Journal:  Opt Lett       Date:  2012-03-15       Impact factor: 3.776

2.  Interstitial Doppler optical coherence tomography.

Authors:  Victor X D Yang; You X Mao; Nigel Munce; Beau Standish; Walter Kucharczyk; Norman E Marcon; Brian C Wilson; I Alex Vitkin
Journal:  Opt Lett       Date:  2005-07-15       Impact factor: 3.776

3.  Performance of fourier domain vs. time domain optical coherence tomography.

Authors:  R Leitgeb; C Hitzenberger; Adolf Fercher
Journal:  Opt Express       Date:  2003-04-21       Impact factor: 3.894

4.  Signal-to-noise ratio analysis of all-fiber common-path optical coherence tomography.

Authors:  Xiaolu Li; Jae-Ho Han; Xuan Liu; Jin U Kang
Journal:  Appl Opt       Date:  2008-09-20       Impact factor: 1.980

5.  Optical coherence tomography.

Authors:  D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito
Journal:  Science       Date:  1991-11-22       Impact factor: 47.728

6.  Design and validation of an angle-resolved low-coherence interferometry fiber probe for in vivo clinical measurements of depth-resolved nuclear morphology.

Authors:  Yizheng Zhu; Neil G Terry; John T Woosley; Nicholas J Shaheen; Adam Wax
Journal:  J Biomed Opt       Date:  2011 Jan-Feb       Impact factor: 3.170

7.  In vivo endoscopic optical biopsy with optical coherence tomography.

Authors:  G J Tearney; M E Brezinski; B E Bouma; S A Boppart; C Pitris; J F Southern; J G Fujimoto
Journal:  Science       Date:  1997-06-27       Impact factor: 47.728

8.  Endoscopic Functional Fourier Domain Common Path Optical Coherence Tomography for Microsurgery.

Authors:  Jin U Kang; Jae-Ho Han; Xuan Liu; Kang Zhang; Chul Gyu Song; Peter Gehlbach
Journal:  IEEE J Sel Top Quantum Electron       Date:  2010-07       Impact factor: 4.544

9.  Single-camera sequential-scan-based polarization-sensitive SDOCT for retinal imaging.

Authors:  Mingtao Zhao; Joseph A Izatt
Journal:  Opt Lett       Date:  2009-01-15       Impact factor: 3.776

10.  Sapphire ball lens-based fiber probe for common-path optical coherence tomography and its applications in corneal and retinal imaging.

Authors:  Mingtao Zhao; Yong Huang; Jin U Kang
Journal:  Opt Lett       Date:  2012-12-01       Impact factor: 3.776

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