OBJECTIVE: An animal model of hemolysis, elevated liver enzymes, low platelet count (HELLP) was used to determine if T lymphocytes accompany hypertension and increased inflammatory cytokines. METHODS: sFlt-1 (4.7 µg/kg/day) and sEndoglin (7 µg/kg/day) were infused into normal pregnant rats (HELLP rats) for 8 days. RESULTS: HELLP was associated with increased mean arterial pressure (p = 0.0001), hemolysis (p = 0.044), elevated liver enzymes (p = 0.027), and reduced platelets (p = 0.035). HELLP rats had increased plasma levels of TNFα (p = 0.039), IL-6 (p = 0.038) and IL-17 (p = 0.04). CD4(+) and CD8(+) T lymphocytes were increased. CONCLUSION: These data support the hypothesis that T cells are associated with hypertension and inflammation.
OBJECTIVE: An animal model of hemolysis, elevated liver enzymes, low platelet count (HELLP) was used to determine if T lymphocytes accompany hypertension and increased inflammatory cytokines. METHODS: sFlt-1 (4.7 µg/kg/day) and sEndoglin (7 µg/kg/day) were infused into normal pregnant rats (HELLP rats) for 8 days. RESULTS: HELLP was associated with increased mean arterial pressure (p = 0.0001), hemolysis (p = 0.044), elevated liver enzymes (p = 0.027), and reduced platelets (p = 0.035). HELLP rats had increased plasma levels of TNFα (p = 0.039), IL-6 (p = 0.038) and IL-17 (p = 0.04). CD4(+) and CD8(+) T lymphocytes were increased. CONCLUSION: These data support the hypothesis that T cells are associated with hypertension and inflammation.
Authors: Sharon D Keiser; Michelle Y Owens; Marc R Parrish; Julie L Cushman; Laura Bufkin; Warren L May; James N Martin Journal: Am J Perinatol Date: 2010-09-08 Impact factor: 1.862
Authors: Gergely Toldi; Peter Svec; Barna Vásárhelyi; Gergö Mészáros; János Rigó; Tivadar Tulassay; András Treszl Journal: Acta Obstet Gynecol Scand Date: 2008 Impact factor: 3.636
Authors: Andrea Steinborn; Gertrud M Haensch; Karsten Mahnke; Edgar Schmitt; Anne Toermer; Stefan Meuer; Christof Sohn Journal: Clin Immunol Date: 2008-09-21 Impact factor: 3.969
Authors: Brigitte Santner-Nanan; Michael John Peek; Roma Khanam; Luise Richarts; Erhua Zhu; Barbara Fazekas de St Groth; Ralph Nanan Journal: J Immunol Date: 2009-11-13 Impact factor: 5.422
Authors: Jelmer R Prins; Hendrik M Boelens; Janneke Heimweg; Sicco Van der Heide; Anthony E Dubois; Antoon J Van Oosterhout; Jan Jaap H M Erwich Journal: Hypertens Pregnancy Date: 2009 Impact factor: 2.108
Authors: Jacob Gibbens; Shauna-Kay Spencer; Lucia Solis; Teylor Bowles; Patrick B Kyle; Jamie L Szczepanski; John Polk Dumas; Reanna Robinson; Kedra Wallace Journal: Am J Physiol Regul Integr Comp Physiol Date: 2020-07-08 Impact factor: 3.619
Authors: Cynthia Bean; Shauna-Kay Spencer; Teylor Bowles; Patrick B Kyle; Jan M Williams; Jacob Gibbens; Kedra Wallace Journal: Am J Reprod Immunol Date: 2016-08-01 Impact factor: 3.886
Authors: Sabrina M Scroggins; Donna A Santillan; Jenna M Lund; Jeremy A Sandgren; Lindsay K Krotz; Wendy S Hamilton; Eric J Devor; Heather A Davis; Gary L Pierce; Katherine N Gibson-Corley; Curt D Sigmund; Justin L Grobe; Mark K Santillan Journal: Clin Sci (Lond) Date: 2018-02-14 Impact factor: 6.124