OBJECTIVE: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients. METHODS: Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry. RESULTS: Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells. CONCLUSION: We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.
OBJECTIVE: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients. METHODS: Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry. RESULTS:Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells. CONCLUSION: We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.
Authors: A Steinborn; E Schmitt; A Kisielewicz; S Rechenberg; N Seissler; K Mahnke; M Schaier; M Zeier; C Sohn Journal: Clin Exp Immunol Date: 2012-01 Impact factor: 4.330
Authors: Vanessa R Ribeiro; Mariana Romao-Veiga; Graziela G Romagnoli; Mariana L Matias; Priscila R Nunes; Vera Therezinha M Borges; Jose C Peracoli; Maria Terezinha S Peracoli Journal: Immunology Date: 2017-06-19 Impact factor: 7.397