Literature DB >> 29897303

T Cells and Hypertension: Solved and Unsolved Mysteries Regarding the Female Rat.

Amrita V Pai1,2, Taylor Maddox3,2, Kathryn Sandberg1,3,2.   

Abstract

T-cell function in female animal models of hypertension is poorly understood since most research is conducted in males. Our findings in Dahl-salt-sensitive and Dahl salt-resistant rats support prior research showing sex-specific T-cell effects in the pathophysiology of hypertension. Further studies are needed to inform clinical studies in both sexes and to provide clues into immune mechanisms underlying susceptibility and resilience to developing hypertension and associated disease.

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Year:  2018        PMID： 29897303      PMCID： PMC6088140          DOI： 10.1152/physiol.00011.2018

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  36 in total

1.  Isolation of double negative αβ T cells from the kidney.

Authors:  Maria N Martina; Samantha Bandapalle; Hamid Rabb; Abdel R Hamad
Journal:  J Vis Exp       Date:  2014-05-16       Impact factor: 1.355

2.  Inhibition of T-cell activation attenuates hypertension, TNFα, IL-17, and blood-brain barrier permeability in pregnant rats with angiogenic imbalance.

Authors:  Cynthia Bean; Shauna-Kay Spencer; Teylor Bowles; Patrick B Kyle; Jan M Williams; Jacob Gibbens; Kedra Wallace
Journal:  Am J Reprod Immunol       Date:  2016-08-01       Impact factor: 3.886

3.  T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats.

Authors:  Carmen De Miguel; Satarupa Das; Hayley Lund; David L Mattson
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-02-10       Impact factor: 3.619

4.  Dexamethasone attenuates development of monocrotaline-induced pulmonary arterial hypertension.

Authors:  Wei Wang; Yu-Lin Wang; Xiao-Ying Chen; Yu-Tang Li; Wei Hao; You-Peng Jin; Bo Han
Journal:  Mol Biol Rep       Date:  2011-03-23       Impact factor: 2.316

5.  Olmesartan, a novel AT1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure.

Authors:  Zuyi Yuan; Masaomi Nimata; Taka-Aki Okabe; Keisuke Shioji; Koji Hasegawa; Toru Kita; Chiharu Kishimoto
Journal:  Am J Physiol Heart Circ Physiol       Date:  2005-05-06       Impact factor: 4.733

Review 6.  Sex-specific immune modulation of primary hypertension.

Authors:  Kathryn Sandberg; Hong Ji; Meredith Hay
Journal:  Cell Immunol       Date:  2014-12-08       Impact factor: 4.868

7.  Restoration of T cell depression and suppression of blood pressure in spontaneously hypertensive rats (SHR) by thymus grafts or thymus extracts.

Authors:  D Ba; N Takeichi; T Kodama; H Kobayashi
Journal:  J Immunol       Date:  1982-03       Impact factor: 5.422

8.  Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension.

Authors:  Jong-Chan Youn; Hee Tae Yu; Beom Jin Lim; Myoung Ju Koh; Jino Lee; Dong-Yeop Chang; Yoon Seok Choi; Sang-Hak Lee; Seok-Min Kang; Yangsoo Jang; Ook Joon Yoo; Eui-Cheol Shin; Sungha Park
Journal:  Hypertension       Date:  2013-05-28       Impact factor: 10.190

9.  Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension.

Authors:  Silvia Ulrich; Mark R Nicolls; Laima Taraseviciene; Rudolf Speich; Norbert Voelkel
Journal:  Respiration       Date:  2007-11-20       Impact factor: 3.580

10.  Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.

Authors:  Heddwen L Brooks; Meredith Hay; Dennis P Pollow; Jennifer Uhrlaub; Melissa Romero-Aleshire; Kathryn Sandberg; Janko Nikolich-Zugich
Journal:  Hypertension       Date:  2014-06-02       Impact factor: 10.190
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  5 in total

1.  Genetic disruption of Npr1 depletes regulatory T cells and provokes high levels of proinflammatory cytokines and fibrosis in the kidneys of female mutant mice.

Authors:  Venkateswara Reddy Gogulamudi; Indra Mani; Umadevi Subramanian; Kailash N Pandey
Journal:  Am J Physiol Renal Physiol       Date:  2019-04-03

2.  Renal T cell infiltration occurs despite attenuation of development of hypertension with hydralazine in Envigo's female Dahl rat maintained on a low-Na+ diet.

Authors:  Amrita V Pai; Crystal A West; Aline M Arlindo de Souza; Parnika S Kadam; Emma J Pollner; David A West; Jia Li; Hong Ji; Xie Wu; Michelle J Zhu; Chris Baylis; Kathryn Sandberg
Journal:  Am J Physiol Renal Physiol       Date:  2019-06-26

Review 3.  Female Sex, a Major Risk Factor for Salt-Sensitive Hypertension.

Authors:  Jessica L Faulkner; Eric J Belin de Chantemèle
Journal:  Curr Hypertens Rep       Date:  2020-10-21       Impact factor: 5.369

Review 4.  Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.

Authors:  Branka Miličić Stanić; Sydney Maddox; Aline M A de Souza; Xie Wu; Danial Mehranfard; Hong Ji; Robert C Speth; Kathryn Sandberg
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2021-04-13       Impact factor: 3.210

Review 5.  Sex differences in redox homeostasis in renal disease.

Authors:  Tanecia Mitchell; Carmen De Miguel; Eman Y Gohar
Journal:  Redox Biol       Date:  2020-03-09       Impact factor: 11.799
  5 in total

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