PURPOSE: To elucidate the possible role of adiponectin, an adipokine secreted by white adipose tissue that plays an important role in the neuromodulation of food intake, in the pathogenesis of eating disorders. METHODS: A comprehensive review of the available literature via MedLine is done using the term "adiponectin" in association with one of the following terms: "anorexia nervosa", "bulimia nervosa", "binge eating disorder" or "eating disorders". RESULTS: The majority of studies evaluating serum adiponectin levels in patients with eating disorders show that serum adiponectin levels are increased in patients with anorexia nervosa. After refeeding, adiponectin levels tend to rejoin the levels of healthy individuals. Data concerning serum adiponectin levels in patients with bulimia nervosa show that these levels can be equal, higher or lower than those found in healthy controls and lower than those found in anorexia nervosa patients. Binge eating disorder is accompanied with lower serum adiponectin levels than normal. Adiponectin receptor type 1 seems to be more related to the central pathological effect of adiponectin on eating behavior. CONCLUSION: The potential role that plays adiponectin in the pathogenesis of eating disorders needs to be elucidated by further studies.
PURPOSE: To elucidate the possible role of adiponectin, an adipokine secreted by white adipose tissue that plays an important role in the neuromodulation of food intake, in the pathogenesis of eating disorders. METHODS: A comprehensive review of the available literature via MedLine is done using the term "adiponectin" in association with one of the following terms: "anorexia nervosa", "bulimia nervosa", "binge eating disorder" or "eating disorders". RESULTS: The majority of studies evaluating serum adiponectin levels in patients with eating disorders show that serum adiponectin levels are increased in patients with anorexia nervosa. After refeeding, adiponectin levels tend to rejoin the levels of healthy individuals. Data concerning serum adiponectin levels in patients with bulimia nervosa show that these levels can be equal, higher or lower than those found in healthy controls and lower than those found in anorexia nervosapatients. Binge eating disorder is accompanied with lower serum adiponectin levels than normal. Adiponectin receptor type 1 seems to be more related to the central pathological effect of adiponectin on eating behavior. CONCLUSION: The potential role that plays adiponectin in the pathogenesis of eating disorders needs to be elucidated by further studies.
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Ximena Terra; Teresa Auguet; Zaida Agüera; Isabel Maria Quesada; Josep Maria Orellana-Gavaldà; Carmen Aguilar; Susana Jiménez-Murcia; Alba Berlanga; Esther Guiu-Jurado; José Manuel Menchón; Fernando Fernández-Aranda; Cristóbal Richart Journal: Int J Eat Disord Date: 2013-07-23 Impact factor: 4.861
Authors: Yong Qi; Nobuhiko Takahashi; Stanley M Hileman; Hiralben R Patel; Anders H Berg; Utpal B Pajvani; Philipp E Scherer; Rexford S Ahima Journal: Nat Med Date: 2004-04-11 Impact factor: 53.440
Authors: Jessica H Baker; Claire M Peterson; Laura M Thornton; Kimberly A Brownley; Cynthia M Bulik; Susan S Girdler; Marsha D Marcus; Joyce T Bromberger Journal: Eur Eat Disord Rev Date: 2017-03-09
Authors: Wenjie Ma; Tao Huang; Yoriko Heianza; Tiange Wang; Dianjianyi Sun; Jenny Tong; Donald A Williamson; George A Bray; Frank M Sacks; Lu Qi Journal: J Clin Endocrinol Metab Date: 2017-01-01 Impact factor: 5.958
Authors: Emily J Yao; Richard K Babbs; Julia C Kelliher; Kimberly P Luttik; Kristyn N Borrelli; M Imad Damaj; Megan K Mulligan; Camron D Bryant Journal: Genes Brain Behav Date: 2021-05-12 Impact factor: 3.708