OBJECTIVE: Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal-weight controls and their relation with the disease duration and weight restoration. METHOD: We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal-weight controls who were eating healthily. We determined by enzyme-linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin-2 (LCN2), leptin, tumor necrosis factor receptor-II (TNFRII), interleukin-6 (IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin, and resistin. RESULTS: The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = -0.372, p = 0.033; r = -0.450, p = 0.038, respectively). Furthermore, the lipid binding-proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = -0.456, p = 0.039; r = -0.536, p = 0.015, respectively). DISCUSSION: These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration.
OBJECTIVE: Starvation-induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal-weight controls and their relation with the disease duration and weight restoration. METHOD: We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal-weight controls who were eating healthily. We determined by enzyme-linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin-2 (LCN2), leptin, tumor necrosis factor receptor-II (TNFRII), interleukin-6 (IL6), adipocyte fatty acid binding protein-4 (FABP4), ghrelin, and resistin. RESULTS: The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = -0.372, p = 0.033; r = -0.450, p = 0.038, respectively). Furthermore, the lipid binding-proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = -0.456, p = 0.039; r = -0.536, p = 0.015, respectively). DISCUSSION: These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration.
Authors: D S Pisetsky; S E Trace; K A Brownley; R M Hamer; N L Zucker; P Roux-Lombard; J-M Dayer; C M Bulik Journal: Cytokine Date: 2014-06-14 Impact factor: 3.861
Authors: Alia A Hussain; Christopher Hübel; Mathias Hindborg; Emilie Lindkvist; Annie M Kastrup; Zeynep Yilmaz; René K Støving; Cynthia M Bulik; Jan M Sjögren Journal: Int J Eat Disord Date: 2019-03-28 Impact factor: 4.861
Authors: Lene Mellemkjaer; Fotios C Papadopoulos; Eero Pukkala; Anders Ekbom; Mika Gissler; Jane Christensen; Jørgen H Olsen Journal: PLoS One Date: 2015-05-22 Impact factor: 3.240
Authors: Zaida Agüera; Xandra Romero; Jon Arcelus; Isabel Sánchez; Nadine Riesco; Susana Jiménez-Murcia; Jana González-Gómez; Roser Granero; Nuria Custal; Monica Montserrat-Gil de Bernabé; Salomé Tárrega; Rosa M Baños; Cristina Botella; Rafael de la Torre; José C Fernández-García; José M Fernández-Real; Gema Frühbeck; Javier Gómez-Ambrosi; Francisco J Tinahones; Ana B Crujeiras; Felipe F Casanueva; José M Menchón; Fernando Fernández-Aranda Journal: PLoS One Date: 2015-11-23 Impact factor: 3.240