Literature DB >> 24374309

Rapid detection of Staphylococcus aureus and methicillin resistance in bone and joint infection samples: evaluation of the GeneXpert MRSA/SA SSTI assay.

Florent Valour1, Viviane Blanc-Pattin2, Anne-Marie Freydière3, Anissa Bouaziz4, Emmanuel Chanard5, Sébastien Lustig6, Tristan Ferry7, Frédéric Laurent8.   

Abstract

The GeneXpert MRSA/SA SSTI assay was compared to conventional cultures to detect Staphylococcus aureus and methicillin-resistance from 91 bone and joint infection samples. Sensitivity and specificity were 94.4% and 100%. Three false-positive results were observed, in fact providing from patients known to be infected by S. aureus on the basis of other concomitant osteoarticular samples, which suggests that PCR was more sensitive than culture. This diagnosis accuracy may help shorten toxic and non-optimal empirical therapies such as glycopeptides in case of methicillin-susceptible strains.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Bone and joint infection; GeneXpert MRSA/SA SSTI assay; Methicillin-resistance; Real time polymerase chain reaction; Staphylococcus aureus

Mesh：

Year:  2013        PMID： 24374309     DOI： 10.1016/j.diagmicrobio.2013.11.026

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  9 in total

1.  Evaluation of the MRSA/SA ELITe MGB Assay for the Detection of Staphylococcus aureus in Bone and Joint Infections.

Authors:  R Labetoulle; J Rigaill; P O Verhoeven; A Carricajo; M Lleres-Vadeboin; F Grattard; B Pozzetto; C Cazorla; E Botelho-Nevers; B Boyer; C Dupieux-Chabert; F Laurent
Journal:  J Clin Microbiol       Date:  2021-11-17       Impact factor: 11.677

2.  Molecular and phenotypic characterization of methicillin-resistant Staphylococcus aureus isolates from a tertiary hospital in the Philippines.

Authors:  Demetrio L Valle; Phyllis Anne P Paclibare; Esperanza C Cabrera; Windell L Rivera
Journal:  Trop Med Health       Date:  2016-03-14

Review 3.  [What place and what future for the pathology of infectious and tropical diseases in France?].

Authors:  Paul Hofman
Journal:  Ann Pathol       Date:  2014-05-20       Impact factor: 0.407

4.  Periprosthetic Joint Infection Prophylaxis in the Elderly after Hip Hemiarthroplasty in Proximal Femur Fractures: Insights and Challenges.

Authors:  Dolors Rodríguez-Pardo; Laura Escolà-Vergé; Júlia Sellarès-Nadal; Pablo S Corona; Benito Almirante; Carles Pigrau
Journal:  Antibiotics (Basel)       Date:  2021-04-13

5.  Detection of Methicillin-Resistant Staphylococcus aureus Infections Using Molecular Methods.

Authors:  Fred C Tenover; Isabella A Tickler
Journal:  Antibiotics (Basel)       Date:  2022-02-12

6.  Clinical Relevance of Xpert MRSA/SA in Guiding Therapeutic Decisions for Staphylococcal Infections: A Diagnostic Test Accuracy Analysis.

Authors:  Suvash Chandra Ojha; Ke Chen; Changfeng Sun; Sarfraz Ahmed; Yun-Jian Sheng; Cun-Liang Deng
Journal:  Infect Dis Ther       Date:  2022-04-22

7.  Molecular Tools for Guiding Therapy in Patients With Staphylococcal Bone and Joint Infections: A Diagnostic Test Accuracy Meta-analysis.

Authors:  Ke Chen; Yanqiu Wang; Yue Yuan; Wen Qin; Yun-Jian Sheng; Sarfraz Ahmed; Changfeng Sun; Cun-Liang Deng; Suvash Chandra Ojha
Journal:  Front Endocrinol (Lausanne)       Date:  2022-07-13       Impact factor: 6.055

Review 8.  Challenging Methicillin Resistance Detection in Bone and Joint Infections: Focus on the MRSA/SA SSTI® Strategy.

Authors:  Marie Titécat; Caroline Loïez; François Demaeght; Jean-Thomas Leclerc; Théo Martin; Hervé Dezèque; Henri Migaud; Eric Senneville
Journal:  Front Med (Lausanne)       Date:  2021-05-17

9.  PCR-based Approaches for the Detection of Clinical Methicillin-resistant Staphylococcus aureus.

Authors:  Ying Liu; Jiang Zhang; Yinduo Ji
Journal:  Open Microbiol J       Date:  2016-04-14
  9 in total

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