Filippo Queirazza1, David M Semple, Stephen M Lawrie. 1. Filippo Queirazza, MD, MRCPsych, Hairmyres Hospital, East Kilbride, Glasgow; David M. Semple, MB ChB, MRCPsych, Division of Psychiatry, University of Edinburgh, Edinburgh, and Hairmyres Hospital, East Kilbride, Glasgow; Stephen M. Lawrie, MD, FRCPsych, Division of Psychiatry, University of Edinburgh, UK.
Abstract
BACKGROUND: The diagnostic category of acute and transient psychotic disorders (ATPD) was introduced in ICD-10. Subsequent studies have called into question its validity and reliability. AIMS: To determine the pattern of diagnostic revision to schizophrenia in first-ever diagnosed ATPD. METHOD: Using data drawn from the Scottish Morbidity Record, we estimated incidence and diagnostic change in first-ever diagnosed ATPD in Scottish hospitals between January 1997 and December 2010 (n = 2923). RESULTS: The average incidence of ATPD was 4.1 per 100 000 population per year. Diagnostic stability was estimated at 53.9% over an average of approximately 4 years of observation. The most common diagnostic shift was to schizophrenia (12.6%), over an average of 1.7 years. Estimates of the transition risks for schizophrenia were 80% at 2.8 years and 90% at 4.6 years. Longer first admission to hospital, younger age at onset and male gender were associated with increased risk and earlier development of schizophrenia. CONCLUSIONS: Routinely collected data suggest that approximately one in eight individuals with first-ever diagnosed ATPD will develop schizophrenia within 3-5 years. Those at high risk of transition may benefit from monitoring for possible diagnostic change.
BACKGROUND: The diagnostic category of acute and transient psychotic disorders (ATPD) was introduced in ICD-10. Subsequent studies have called into question its validity and reliability. AIMS: To determine the pattern of diagnostic revision to schizophrenia in first-ever diagnosed ATPD. METHOD: Using data drawn from the Scottish Morbidity Record, we estimated incidence and diagnostic change in first-ever diagnosed ATPD in Scottish hospitals between January 1997 and December 2010 (n = 2923). RESULTS: The average incidence of ATPD was 4.1 per 100 000 population per year. Diagnostic stability was estimated at 53.9% over an average of approximately 4 years of observation. The most common diagnostic shift was to schizophrenia (12.6%), over an average of 1.7 years. Estimates of the transition risks for schizophrenia were 80% at 2.8 years and 90% at 4.6 years. Longer first admission to hospital, younger age at onset and male gender were associated with increased risk and earlier development of schizophrenia. CONCLUSIONS: Routinely collected data suggest that approximately one in eight individuals with first-ever diagnosed ATPD will develop schizophrenia within 3-5 years. Those at high risk of transition may benefit from monitoring for possible diagnostic change.
Authors: Philip B Cawkwell; Kirsten W Bolton; Rakesh Karmacharya; Dost Öngür; Ann K Shinn Journal: Early Interv Psychiatry Date: 2020-02-10 Impact factor: 2.732
Authors: Lucia R Valmaggia; Majella Byrne; Fern Day; Matthew R Broome; Louise Johns; Oliver Howes; Paddy Power; Steven Badger; Paolo Fusar-Poli; Philip K McGuire Journal: Br J Psychiatry Date: 2015-06-04 Impact factor: 9.319
Authors: Paolo Fusar-Poli; Marco Cappucciati; Grazia Rutigliano; Margaret Heslin; Daniel Stahl; Zera Brittenden; Edgardo Caverzasi; Philip McGuire; William T Carpenter Journal: Schizophr Bull Date: 2016-03-15 Impact factor: 9.306
Authors: Paolo Fusar-Poli; Marco Cappucciati; Andrea De Micheli; Grazia Rutigliano; Ilaria Bonoldi; Stefania Tognin; Valentina Ramella-Cravaro; Augusto Castagnini; Philip McGuire Journal: Schizophr Bull Date: 2017-01 Impact factor: 9.306
Authors: Samuel P Leighton; Rajeev Krishnadas; Kelly Chung; Alison Blair; Susie Brown; Suzy Clark; Kathryn Sowerbutts; Matthias Schwannauer; Jonathan Cavanagh; Andrew I Gumley Journal: PLoS One Date: 2019-03-07 Impact factor: 3.240