| Literature DB >> 24350818 |
Zhenyu Lu1, Ryan M Van Wagoner, Cristopher D Pond, Ann R Pole, James B Jensen, D'Arbra Blankenship, Brian T Grimberg, Robert Kiapranis, Teatulohi K Matainaho, Louis R Barrows, Chris M Ireland.
Abstract
An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-μM range.Entities:
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Year: 2013 PMID： 24350818 PMCID： PMC3923365 DOI： 10.1021/ol4022639
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005