Literature DB >> 15783174

(+)-Myristinin A, a naturally occurring DNA polymerase beta inhibitor and potent DNA-damaging agent.

David J Maloney1, Jing-Zhen Deng, Shelley R Starck, Zhijie Gao, Sidney M Hecht.   

Abstract

The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute stereochemistry. Myristinin A exhibits biochemical activity both as a potent DNA-damaging agent and DNA polymerase beta inhibitor. Relaxation of supercoiled plasmid DNA was observed at picomolar concentrations, in addition to inhibition of polymerase beta at low micromolar concentrations.

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Year:  2005        PMID： 15783174     DOI： 10.1021/ja042727j

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  11 in total

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Journal:  Org Lett       Date:  2013-12-19       Impact factor: 6.005

6.  Biomimetic Approach to the Catalytic Enantioselective Synthesis of Flavonoids.

Authors:  Zhenyu Yang; Ying He; F Dean Toste
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7.  Stereochemical control in the reduction of 2-chromanols.

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Review 8.  Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.

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9.  Enantioselective addition of boronates to o-quinone methides catalyzed by chiral biphenols.

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Journal:  J Am Chem Soc       Date:  2014-11-12       Impact factor: 15.419
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