PURPOSE: The aim of this study was to develop, implement, and demonstrate a three-dimensional (3D) extension of the readout-segmented echo-planar imaging (rs-EPI) sequence for diffusion imaging. THEORY AND METHODS: Potential k-space acquisition schemes were assessed by simulating their associated spatial point spread functions. Motion-induced phase artifacts were also simulated to test navigator corrections and a real-time reordering of the k-space acquisition relative to the cardiac cycle. The cardiac reordering strategy preferentially chooses readout segments closer to the center of 3D k-space during diastole. Motion-induced phase artifacts were quantified by calculating the voxel-wise temporal variation in a set of repeated diffusion-weighted acquisitions. Based on the results of these simulations, a 2D navigated multi-slab rs-EPI sequence with real-time cardiac reordering was implemented. The multi-slab implementation enables signal-to-noise ratio-optimal repetition times of 1-2 s. RESULTS: Cardiac reordering was validated in simulations and in vivo using the multi-slab rs-EPI sequence. In comparisons with standard k-space acquisitions, cardiac reordering was shown to reduce the variability due to motion-induced phase artifacts by 30-50%. High-resolution diffusion tensor imaging data acquired with the cardiac-reordered multi-slab rs-EPI sequence are presented. CONCLUSION: A 3D multi-slab rs-EPI sequence with cardiac reordering has been demonstrated in vivo and is shown to provide high-quality 3D diffusion-weighted data sets.
PURPOSE: The aim of this study was to develop, implement, and demonstrate a three-dimensional (3D) extension of the readout-segmented echo-planar imaging (rs-EPI) sequence for diffusion imaging. THEORY AND METHODS: Potential k-space acquisition schemes were assessed by simulating their associated spatial point spread functions. Motion-induced phase artifacts were also simulated to test navigator corrections and a real-time reordering of the k-space acquisition relative to the cardiac cycle. The cardiac reordering strategy preferentially chooses readout segments closer to the center of 3D k-space during diastole. Motion-induced phase artifacts were quantified by calculating the voxel-wise temporal variation in a set of repeated diffusion-weighted acquisitions. Based on the results of these simulations, a 2D navigated multi-slab rs-EPI sequence with real-time cardiac reordering was implemented. The multi-slab implementation enables signal-to-noise ratio-optimal repetition times of 1-2 s. RESULTS: Cardiac reordering was validated in simulations and in vivo using the multi-slab rs-EPI sequence. In comparisons with standard k-space acquisitions, cardiac reordering was shown to reduce the variability due to motion-induced phase artifacts by 30-50%. High-resolution diffusion tensor imaging data acquired with the cardiac-reordered multi-slab rs-EPI sequence are presented. CONCLUSION: A 3D multi-slab rs-EPI sequence with cardiac reordering has been demonstrated in vivo and is shown to provide high-quality 3D diffusion-weighted data sets.
Authors: Kawin Setsompop; Qiuyun Fan; Jason Stockmann; Berkin Bilgic; Susie Huang; Stephen F Cauley; Aapo Nummenmaa; Fuyixue Wang; Yogesh Rathi; Thomas Witzel; Lawrence L Wald Journal: Magn Reson Med Date: 2017-03-05 Impact factor: 4.668
Authors: Congyu Liao; Jason Stockmann; Qiyuan Tian; Berkin Bilgic; Nicolas S Arango; Mary Kate Manhard; Susie Y Huang; William A Grissom; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2019-08-01 Impact factor: 4.668
Authors: Fuyixue Wang; Berkin Bilgic; Zijing Dong; Mary Kate Manhard; Ned Ohringer; Bo Zhao; Melissa Haskell; Stephen F Cauley; Qiuyun Fan; Thomas Witzel; Elfar Adalsteinsson; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2018-04-01 Impact factor: 4.668
Authors: Wenchuan Wu; Benedikt A Poser; Gwenaëlle Douaud; Robert Frost; Myung-Ho In; Oliver Speck; Peter J Koopmans; Karla L Miller Journal: Neuroimage Date: 2016-08-26 Impact factor: 6.556