| Literature DB >> 24326338 |
Takuji Nakashima1, Masato Iwatsuki2, Junya Ochiai3, Yoshiyuki Kamiya3, Kenichiro Nagai4, Atsuko Matsumoto2, Aki Ishiyama5, Kazuhiko Otoguro5, Kazuro Shiomi2, Yōko Takahashi2, Satoshi Ōmura5.
Abstract
Two new cyclopentadecane antibiotics, named mangromicins A and B, were separated out from the culture broth of Lechevalieria aerocolonigenes K10-0216 by Diaion HP-20, silica gel and ODS column chromatography, and were finally purified by HPLC. The chemical structures of the two novel compounds were elucidated by instrumental analyses, including various NMR, MS and X-ray crystallography. Mangromicins A and B consist of cyclopentadecane skeletons with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety. Mangromicins A and B showed in vitro antitrypanosomal activity with IC50 values of 2.4 and 43.4 μg ml(-1), respectively. The IC50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells.Entities:
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Year: 2013 PMID： 24326338 DOI： 10.1038/ja.2013.129
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649