Literature DB >> 27025350

Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306.

Tōru Kimura1, Masato Iwatsuki1,2, Yukihiro Asami1,2, Aki Ishiyama1,2, Rei Hokari2, Kazuhiko Otoguro2, Atsuko Matsumoto1,2, Noriko Sato3, Kazuro Shiomi1,2, Yōko Takahashi2, Satoshi Ōmura2, Takuji Nakashima2.   

Abstract

A new antibiotic, designated sagamilactam, was isolated from the cultured broth of Actinomadura sp. K13-0306 by Diaion HP-20, silica gel and octadecylsilane column chromatography followed by purification by HPLC. The chemical structure of the new compound was elucidated by spectroscopic analyses, including NMR and MS. The structure of sagamilactam proved to be a new compound consisting of a polyunsaturated and polyoxygenated 34-membered macrocyclic lactam containing diene, triene and tetraene conjugated olefins and a decalin moiety. Sagamilactam showed antitrypanosomal activity with an IC50 value of 0.25±0.11 μM.

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Year:  2016        PMID： 27025350     DOI： 10.1038/ja.2016.28

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  20 in total

1.  Mangromicin C, a new analog of mangromicin.

Authors:  Takuji Nakashima; Yoshiyuki Kamiya; Masato Iwatsuki; Noriko Sato; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2014-10-01       Impact factor: 2.649

2.  Micromonosporin A, a novel 24-membered polyene lactam macrolide from Micromonospora sp. isolated from peat swamp forest.

Authors:  Chitti Thawai; Prasat Kittakoop; Somboon Tanasupawat; Khanit Suwanborirux; Kanlayanee Sriklung; Yodhathai Thebtaranonth
Journal:  Chem Biodivers       Date:  2004-04       Impact factor: 2.408

3.  Potent antimalarial activities of polyether antibiotic, X-206.

Authors:  K Otoguro; A Kohana; C Manabe; A Ishiyama; H Ui; K Shiomi; H Yamada; S Omura
Journal:  J Antibiot (Tokyo)       Date:  2001-08       Impact factor: 2.649

4.  Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).

Authors:  Yuki Inahashi; Masato Iwatsuki; Aki Ishiyama; Miyuki Namatame; Aki Nishihara-Tsukashima; Atsuko Matsumoto; Tomoyasu Hirose; Toshiaki Sunazuka; Haruki Yamada; Kazuhiko Otoguro; Yōko Takahashi; Satoshi Omura; Kazuro Shiomi
Journal:  J Antibiot (Tokyo)       Date:  2011-03-09       Impact factor: 2.649

5.  Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216.

Authors:  Takuji Nakashima; Masato Iwatsuki; Junya Ochiai; Yoshiyuki Kamiya; Kenichiro Nagai; Atsuko Matsumoto; Aki Ishiyama; Kazuhiko Otoguro; Kazuro Shiomi; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2013-12-11       Impact factor: 2.649

6.  Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510.

Authors:  Takuji Nakashima; Ryuki Okuyama; Yoshiyuki Kamiya; Atsuko Matsumoto; Masato Iwatsuki; Yuki Inahashi; Kenzaburo Yamaji; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2013-04-17       Impact factor: 2.649

7.  Actinomadura bangladeshensis sp. nov. and Actinomadura chokoriensis sp. nov.

Authors:  Ismet Ara; Atsuko Matsumoto; Mohammad Abdul Bakir; Takuji Kudo; Satoshi Omura; Yoko Takahashi
Journal:  Int J Syst Evol Microbiol       Date:  2008-07       Impact factor: 2.747

8.  Mangromicins, six new anti-oxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216.

Authors:  Takuji Nakashima; Yoshiyuki Kamiya; Masato Iwatsuki; Yōko Takahashi; Satoshi Ōmura
Journal:  J Antibiot (Tokyo)       Date:  2014-04-02       Impact factor: 2.649

9.  Chemical modification of hitachimycin. Synthesis, antibacterial, cytocidal and in vivo antitumor activities of hitachimycin derivatives.

Authors:  K Shibata; S Satsumabayashi; H Sano; K Komiyama; A Nakagawa; S Omura
Journal:  J Antibiot (Tokyo)       Date:  1988-05       Impact factor: 2.649

10.  Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.

Authors:  Dong-Chan Oh; Michael Poulsen; Cameron R Currie; Jon Clardy
Journal:  Org Lett       Date:  2011-01-19       Impact factor: 6.005
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  5 in total

1.  Structure elucidation and in silico docking studies of a novel furopyrimidine antibiotics synthesized by endolithic bacterium Actinomadura sp. AL2.

Authors:  Kaushik Bhattacharjee; Shakti Kumar; Narasinga Rao Palepu; Pradeep Kumar Patra; Kollipara Mohan Rao; Santa Ram Joshi
Journal:  World J Microbiol Biotechnol       Date:  2017-09-20       Impact factor: 3.312

2.  Structural Reassignment and Absolute Stereochemistry of Madurastatin C1 (MBJ-0034) and the Related Aziridine Siderophores: Madurastatins A1, B1, and MBJ-0035.

Authors:  Andrew R Tyler; Hamed Mosaei; Stephanie Morton; Paul G Waddell; Corinne Wills; William McFarlane; Joe Gray; Michael Goodfellow; Jeff Errington; Nick Allenby; Nikolay Zenkin; Michael J Hall
Journal:  J Nat Prod       Date:  2017-04-11       Impact factor: 4.050

Review 3.  Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities.

Authors:  Wei Zhao; Hong Jiang; Xiao-Wan Liu; Jian Zhou; Bin Wu
Journal:  Mar Drugs       Date:  2022-05-27       Impact factor: 6.085

Review 4.  The secondary metabolites of rare actinomycetes: chemistry and bioactivity.

Authors:  Ting Ding; Luo-Jie Yang; Wei-Dong Zhang; Yun-Heng Shen
Journal:  RSC Adv       Date:  2019-07-16       Impact factor: 4.036

Review 5.  Actinomycetes, an Inexhaustible Source of Naturally Occurring Antibiotics.

Authors:  Yōko Takahashi; Takuji Nakashima
Journal:  Antibiotics (Basel)       Date:  2018-05-24
  5 in total

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