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Literature DB >> 2432596

Human autoantibodies reactive with the signal-recognition particle.

Abstract

We describe autoantibodies reactive with the signal-recognition particle (SRP) in serum of a patient with polymyositis. The serum specifically immunoprecipitated the SRP from human erythroleukemia (K562) cell extracts. Analysis of immunoblots revealed that the serum contained autoantibodies specific for the 54-kDa protein of the SRP but had little or no reactivity with its other five proteins. Indirect immunofluorescence of human laryngeal carcinoma (HEp-2) cells confirmed that the ribonucleoprotein immunoprecipitated by this serum is found mainly in the cytoplasm. This autoimmune serum may be useful for studying the function of the 54-kDa subunit of the SRP in binding to signal sequences or in interacting with other components of the translational machinery.

Entities: Disease Species

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Year: 1986 PMID： 2432596 PMCID： PMC387169 DOI： 10.1073/pnas.83.24.9507

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

1. Psoriasis and Raynaud's phenomenon associated with autoantibodies to U1 and U2 small nuclear ribonucleoproteins.

Authors: W H Reeves; D E Fisher; R Wisniewolski; A B Gottlieb; N Chiorazzi
Journal: N Engl J Med Date: 1986-07-10 Impact factor: 91.245

2. Characterization and subcellular localization of 7-8 S RNAs of Novikoff hepatoma.

Authors: R Reddy; W Y Li; D Henning; Y C Choi; K Nohga; H Busch
Journal: J Biol Chem Date: 1981-08-25 Impact factor: 5.157

3. Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.

Authors: P Walter; G Blobel
Journal: Nature Date: 1982-10-21 Impact factor: 49.962

4. Cloning and characterization of cDNA copies of the 7S RNAs of HeLa cells.

Authors: E Ullu; M Melli
Journal: Nucleic Acids Res Date: 1982-04-10 Impact factor: 16.971

5. Secretory protein translocation across membranes-the role of the "docking protein'.

Authors: D I Meyer; E Krause; B Dobberstein
Journal: Nature Date: 1982-06-24 Impact factor: 49.962

6. Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an alu sequence.

Authors: E Ullu; S Murphy; M Melli
Journal: Cell Date: 1982-05 Impact factor: 41.582

7. Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La lupus antibodies.

Authors: J Rinke; J A Steitz
Journal: Cell Date: 1982-05 Impact factor: 41.582

8. Immunoglobulin M autoantibody to vimentin intermediate filaments.

Authors: J L Senecal; N F Rothfield; J M Oliver
Journal: J Clin Invest Date: 1982-03 Impact factor: 14.808

9. Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

Authors: P Walter; G Blobel
Journal: J Cell Biol Date: 1981-11 Impact factor: 10.539

10. Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders.

Authors: G E Conner; D Nelson; R Wisniewolski; R G Lahita; G Blobel; H G Kunkel
Journal: J Exp Med Date: 1982-11-01 Impact factor: 14.307

41 in total

1. Monomeric scAlu and nascent dimeric Alu RNAs induced by adenovirus are assembled into SRP9/14-containing RNPs in HeLa cells.

Authors: D Y Chang; K Hsu; R J Maraia
Journal: Nucleic Acids Res Date: 1996-11-01 Impact factor: 16.971

Review 2. Myositis-specific autoantibodies: detection and clinical associations.

Authors: Sander H J van Dooren; Walther J van Venrooij; Ger J M Pruijn
Journal: Auto Immun Highlights Date: 2011-03-23

Review 3. Immune-Mediated Necrotizing Myopathy: Update on Diagnosis and Management.

Authors: Pari Basharat; Lisa Christopher-Stine
Journal: Curr Rheumatol Rep Date: 2015-12 Impact factor: 4.592

Review 4. Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases.

Authors: Antony Rosen; Livia Casciola-Rosen
Journal: Annu Rev Immunol Date: 2016-02-22 Impact factor: 28.527

Review 5. Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis.

Authors: Andrew L Mammen
Journal: Nat Rev Neurol Date: 2011-06-08 Impact factor: 42.937

Review 6. Immune-mediated necrotizing myopathy.

Authors: C Bergua; H Chiavelli; J P Simon; O Boyer; F Jouen; W Stenzel; J Martinet
Journal: Z Rheumatol Date: 2016-03 Impact factor: 1.372

Review 7. Potential Pathogenic Role of Anti-Signal Recognition Protein and Anti-3-hydroxy-3-methylglutaryl-CoA Reductase Antibodies in Immune-Mediated Necrotizing Myopathies.

Authors: Leandro Ladislau; Louiza Arouche-Delaperche; Yves Allenbach; Olivier Benveniste
Journal: Curr Rheumatol Rep Date: 2018-08-03 Impact factor: 4.592

8. Anti-KJ: a new antibody associated with the syndrome of polymyositis and interstitial lung disease.

Authors: I N Targoff; F C Arnett; L Berman; C O'Brien; M Reichlin
Journal: J Clin Invest Date: 1989-07 Impact factor: 14.808

9. Heterogeneous clinical spectrum of anti-SRP myositis and importance of the methods of detection of anti-SRP autoantibodies: a multicentric study.

Authors: Cécile Picard; Thierry Vincent; Jean-Christophe Lega; Sophie Hue; Françoise Fortenfant; Daniela Lakomy; René-Louis Humbel; Joelle Goetz; Nicolas Molinari; Nathalie Bardin; Daniel Bertin; Catherine Johanet; Pascale Chretien; Sylvain Dubucquoi; Nathalie Streichenberger; Sophie Desplat-Jégo; Xavier Bossuyt; Jean Sibilia; Isabelle Abreu; Alain Chevailler; Nicole Fabien
Journal: Immunol Res Date: 2016-06 Impact factor: 2.829

Review 10. Laboratory evaluation of the inflammatory myopathies.

Authors: L G Rider; F W Miller
Journal: Clin Diagn Lab Immunol Date: 1995-01