Literature DB >> 24323884

Polyarginine induces an antitumor immune response through binding to toll-like receptor 4.

Yong Yang1, Joy Wolfram, Xiaohong Fang, Haifa Shen, Mauro Ferrari.   

Abstract

A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cancer immunotherapy; polyarginine; single-molecule fluorescence imaging; single-molecule force measurement

Mesh：

Substances：

Year:  2013        PMID： 24323884      PMCID： PMC4116740          DOI： 10.1002/smll.201302887

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  22 in total

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  9 in total

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