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Literature DB >> 24656615

The nano-plasma interface: Implications of the protein corona.

Joy Wolfram¹, Yong Yang², Jianliang Shen³, Asad Moten⁴, Chunying Chen⁵, Haifa Shen⁶, Mauro Ferrari⁷, Yuliang Zhao⁸.

Abstract

The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

Entities: Chemical Disease Gene Species

Keywords: Nano-bio interface; Nanoparticles; Plasma; Protein corona; Proteins

Mesh：

Substances：
Proteins

Year: 2014 PMID： 24656615 PMCID： PMC4152388 DOI： 10.1016/j.colsurfb.2014.02.035

Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268

89 in total

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4. Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

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Review 6. Protein nanoparticles as drug carriers in clinical medicine.

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7. Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol-DOPE/DNA lipoplexes in serum.

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Review 8. Nanoparticle therapeutics: an emerging treatment modality for cancer.

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9. Influence of protein corona on the transport of molecules into cells by mesoporous silica nanoparticles.

Authors: Amauri J Paula; Roberto T Araujo Júnior; Diego Stéfani T Martinez; Edgar J Paredes-Gamero; Helena B Nader; Nelson Durán; Giselle Z Justo; Oswaldo Luiz Alves
Journal: ACS Appl Mater Interfaces Date: 2013-07-25 Impact factor: 9.229

10. Nucleation of protein fibrillation by nanoparticles.

Authors: Sara Linse; Celia Cabaleiro-Lago; Wei-Feng Xue; Iseult Lynch; Stina Lindman; Eva Thulin; Sheena E Radford; Kenneth A Dawson
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37 in total

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4. A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis.

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Review 5. Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles.

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6. Stealth filaments: Polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X.

Authors: Karin L Lee; Sourabh Shukla; Mengzhi Wu; Nadia R Ayat; Caroline E El Sanadi; Amy M Wen; John F Edelbrock; Jonathan K Pokorski; Ulrich Commandeur; George R Dubyak; Nicole F Steinmetz
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