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Literature DB >> 24323038

Dose-finding trial designs for combination therapies in oncology.

Sumithra J Mandrekar¹.
1. Mayo Clinic, Rochester, MN.

Abstract

Mesh：

Substances：

Year: 2013 PMID： 24323038 DOI： 10.1200/JCO.2013.52.9198

Source DB: PubMed Journal: J Clin Oncol ISSN： 0732-183X Impact factor: 44.544

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13 in total

Review 1. The changing landscape of phase I trials in oncology.

Authors: Kit Man Wong; Anna Capasso; S Gail Eckhardt
Journal: Nat Rev Clin Oncol Date: 2015-11-10 Impact factor: 66.675

2. Identifying a maximum tolerated contour in two-dimensional dose finding.

Authors: Nolan A Wages
Journal: Stat Med Date: 2016-02-22 Impact factor: 2.373

3. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies.

Authors: Akihiro Hirakawa; Nolan A Wages; Hiroyuki Sato; Shigeyuki Matsui
Journal: Stat Med Date: 2015-05-13 Impact factor: 2.373

Review 4. Implementation of adaptive methods in early-phase clinical trials.

Authors: Gina R Petroni; Nolan A Wages; Gautier Paux; Frédéric Dubois
Journal: Stat Med Date: 2016-02-29 Impact factor: 2.373

Review 5. Practical designs for Phase I combination studies in oncology.

Authors: Nolan A Wages; Anastasia Ivanova; Olga Marchenko
Journal: J Biopharm Stat Date: 2016 Impact factor: 1.051

Review 6. The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

Authors: E M J van Brummelen; A D R Huitema; E van Werkhoven; J H Beijnen; J H M Schellens
Journal: J Pharmacokinet Pharmacodyn Date: 2016-03-10 Impact factor: 2.745

Dose-finding trial designs for combination therapies in oncology.

Review 1. The changing landscape of phase I trials in oncology.

2. Identifying a maximum tolerated contour in two-dimensional dose finding.

3. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies.

Review 4. Implementation of adaptive methods in early-phase clinical trials.

Review 5. Practical designs for Phase I combination studies in oncology.

Review 6. The performance of model-based versus rule-based phase I clinical trials in oncology : A quantitative comparison of the performance of model-based versus rule-based phase I trials with molecularly targeted anticancer drugs over the last 2 years.

7. Dose-finding designs for trials of molecularly targeted agents and immunotherapies.

8. Keyboard: A Novel Bayesian Toxicity Probability Interval Design for Phase I Clinical Trials.

9. Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine.

10. Designing Dose-Finding Phase I Clinical Trials: Top 10 Questions That Should Be Discussed With Your Statistician.