Literature DB >> 85165

Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.

I Grundke-Iqbal, A B Johnson, H M Wisniewski, R D Terry, K Iqbal.   

Abstract

Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in tissue sections by the peroxidase-antiperoxidase technique. These results indicate that neurofibrillary tangles in Alzheimer's disease probably originate from neurotubules.

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Year:  1979        PMID： 85165     DOI： 10.1016/s0140-6736(79)91006-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  36 in total

1.  Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

Authors:  M C Haugh; A Probst; J Ulrich; J Kahn; B H Anderton
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-11       Impact factor: 10.154

2.  Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2.

Authors:  S H Yen; D W Dickson; A Crowe; M Butler; M L Shelanski
Journal:  Am J Pathol       Date:  1987-01       Impact factor: 4.307

3.  Aluminum neurotoxicity in mammals.

Authors:  H M Wisniewski; R C Moretz; J A Sturman; G Y Wen; J W Shek
Journal:  Environ Geochem Health       Date:  1990-03       Impact factor: 4.609

4.  Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease.

Authors:  H M Wisniewski; C Bancher; M Barcikowska; G Y Wen; J Currie
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

5.  Intracellular neurofibrillary tangle-like aggregations. A constantly present amyloid alteration in the aging choroid plexus.

Authors:  L Eriksson; P Westermark
Journal:  Am J Pathol       Date:  1986-10       Impact factor: 4.307

6.  Alzheimer paired helical filaments: immunochemical identification of polypeptides.

Authors:  I Grundke-Iqbal; K Iqbal; Y C Tung; H M Wisniewski
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

7.  Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion.

Authors:  T Shirahama; M Skinner; P Westermark; A Rubinow; A S Cohen; A Brun; T L Kemper
Journal:  Am J Pathol       Date:  1982-04       Impact factor: 4.307

8.  Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles.

Authors:  S Yagishita; Y Itoh; W Nan; N Amano
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088

9.  An immunocytochemical comparison of cytoskeletal proteins in aluminum-induced and Alzheimer-type neurofibrillary tangles.

Authors:  D Munoz-Garcia; W W Pendlebury; J B Kessler; D P Perl
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

10.  Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

Authors:  K S Kosik; L K Duffy; M M Dowling; C Abraham; A McCluskey; D J Selkoe
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205
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