| Literature DB >> 24316982 |
Nancy A Jenkins1, Neal G Copeland1, Emilie A Bard-Chapeau1, Anh-Tuan Nguyen1, Alistair G Rust2, Ahmed Sayadi1, Philip Lee3, Belinda Q Chua1, Lee-Sun New4, Johann de Jong5, Jerrold M Ward1, Christopher Ky Chin1, Valerie Chew6, Han Chong Toh7, Jean-Pierre Abastado6, Touati Benoukraf8, Richie Soong8, Frederic A Bard1, Adam J Dupuy9, Randy L Johnson10, George K Radda3, Eric Cy Chan4, Lodewyk Fa Wessels5, David J Adams2.
Abstract
The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC.Entities:
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Year: 2013 PMID： 24316982 PMCID： PMC4131144 DOI： 10.1038/ng.2847
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330