| Literature DB >> 24315455 |
Matthias R Bauer1, Frank M Boeckler.
Abstract
In this issue of Structure, Bista and colleagues report that inhibitors of the MDM2/p53 interaction can be designed to interact with a transiently folded α-helical segment of the MDM2 lid region. This suggests that targeting transient protein states in PPI inhibitor design could be a promising strategy to improve affinity and/or selectivity profiles.Entities:
Mesh：
Substances：
Year: 2013 PMID： 24315455 DOI： 10.1016/j.str.2013.11.003
Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006