Literature DB >> 24310213

Natural product libraries: assembly, maintenance, and screening.

Mark S Butler1, Frank Fontaine1, Matthew A Cooper1.   

Abstract

This review discusses successful strategies and potential pitfalls to assembling a natural product-based library suitable for high-throughput screening. Specific extraction methods for plants, microorganisms, and marine invertebrates are detailed, along with methods for generating a fractionated sub-library. The best methods to store, maintain and prepare the library for screening are addressed, as well as recommendations on how to develop a robust high-throughput assay. Finally, the logistics of moving from an assay hit to pure bioactive compound are discussed. Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2013        PMID： 24310213     DOI： 10.1055/s-0033-1360109

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  16 in total

1.  Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins.

Authors:  Tyler A Johnson; Laura Milan-Lobo; Tao Che; Madeline Ferwerda; Eptisam Lambu; Nicole L McIntosh; Fei Li; Li He; Nicholas Lorig-Roach; Phillip Crews; Jennifer L Whistler
Journal:  ACS Chem Neurosci       Date:  2016-11-22       Impact factor: 4.418

2.  NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening.

Authors:  Christopher C Thornburg; John R Britt; Jason R Evans; Rhone K Akee; James A Whitt; Spencer K Trinh; Matthew J Harris; Jerell R Thompson; Teresa L Ewing; Suzanne M Shipley; Paul G Grothaus; David J Newman; Joel P Schneider; Tanja Grkovic; Barry R O'Keefe
Journal:  ACS Chem Biol       Date:  2018-06-13       Impact factor: 5.100

3.  Metabolomics meets functional assays: coupling LC-MS and microfluidic cell-based receptor-ligand analyses.

Authors:  M G L Henquet; M Roelse; R C H de Vos; A Schipper; G Polder; N C A de Ruijter; R D Hall; M A Jongsma
Journal:  Metabolomics       Date:  2016-06-22       Impact factor: 4.290

4.  A Dereplication and Bioguided Discovery Approach to Reveal New Compounds from a Marine-Derived Fungus Stilbella fimetaria.

Authors:  Sara Kildgaard; Karolina Subko; Emma Phillips; Violaine Goidts; Mercedes de la Cruz; Caridad Díaz; Charlotte H Gotfredsen; Birgitte Andersen; Jens C Frisvad; Kristian F Nielsen; Thomas O Larsen
Journal:  Mar Drugs       Date:  2017-08-13       Impact factor: 5.118

Review 5.  Screening and identification of novel biologically active natural compounds.

Authors:  David Newman
Journal:  F1000Res       Date:  2017-06-05

6.  A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans.

Authors:  Julia Zwirchmayr; Benjamin Kirchweger; Theresa Lehner; Ammar Tahir; Dagmar Pretsch; Judith M Rollinger
Journal:  Sci Rep       Date:  2020-07-23       Impact factor: 4.379

Review 7.  Solvent Supercritical Fluid Technologies to Extract Bioactive Compounds from Natural Sources: A Review.

Authors:  Kooi-Yeong Khaw; Marie-Odile Parat; Paul Nicholas Shaw; James Robert Falconer
Journal:  Molecules       Date:  2017-07-14       Impact factor: 4.411

Review 8.  Antibacterial Discovery and Development: From Gene to Product and Back.

Authors:  Victor Fedorenko; Olga Genilloud; Liliya Horbal; Giorgia Letizia Marcone; Flavia Marinelli; Yossi Paitan; Eliora Z Ron
Journal:  Biomed Res Int       Date:  2015-08-03       Impact factor: 3.411

9.  Prioritization of anti-malarial hits from nature: chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs.

Authors:  Samuel Ayodele Egieyeh; James Syce; Sarel F Malan; Alan Christoffels
Journal:  Malar J       Date:  2016-01-29       Impact factor: 2.979

Review 10.  Epigenetic assays for chemical biology and drug discovery.

Authors:  Sheraz Gul
Journal:  Clin Epigenetics       Date:  2017-04-21       Impact factor: 6.551
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