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Literature DB >> 2430977

Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopes.

Abstract

The accompanying report (Watanabe, M., A. L. Frelinger III, and U. Rutishauser, 1986, J. Cell Biol., 103:1721-1727) describes a set of monoclonal antibodies (mAbs) directed against N-CAM epitopes representing the known major structural and functional domains of the molecule. In this study, we have generated and separated a variety of peptide fragments from N-CAM, and then used their size and reactivity with each antibody to position the antigenic sites along the peptide chain. This epitope map, together with the biological properties of the antibodies and previous studies on N-CAM, have been used to construct a topographical model for the molecule in the cell membrane.

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Year: 1986 PMID： 2430977 PMCID： PMC2114365 DOI： 10.1083/jcb.103.5.1729

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

25 in total

1. Binding properties of a cell adhesion molecule from neural tissue.

Authors: U Rutishauser; S Hoffman; G M Edelman
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

2. Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.

Authors: J B Rothbard; R Brackenbury; B A Cunningham; G M Edelman
Journal: J Biol Chem Date: 1982-09-25 Impact factor: 5.157

3. Enzyme-linked immunosorbent assay of the D2-glycoprotein.

Authors: S Ibsen; V Berezin; B Nørgaard-Pedersen; E Bock
Journal: J Neurochem Date: 1983-08 Impact factor: 5.372

4. Mapping the fodrin molecule with monoclonal antibodies. A general approach for rod-like multidomain proteins.

Authors: J R Glenney; P Glenney; K Weber
Journal: J Mol Biol Date: 1983-06-25 Impact factor: 5.469

5. Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.

Authors: S Hoffman; B C Sorkin; P C White; R Brackenbury; R Mailhammer; U Rutishauser; B A Cunningham; G M Edelman
Journal: J Biol Chem Date: 1982-07-10 Impact factor: 5.157

6. Occurrence of alpha 2-8 linked polysialosyl units in a neural cell adhesion molecule.

Authors: J Finne; U Finne; H Deagostini-Bazin; C Goridis
Journal: Biochem Biophys Res Commun Date: 1983-04-29 Impact factor: 3.575

7. Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions.

Authors: B A Cunningham; S Hoffman; U Rutishauser; J J Hemperly; G M Edelman
Journal: Proc Natl Acad Sci U S A Date: 1983-05 Impact factor: 11.205

8. Alternatively spliced mRNAs code for different polypeptide chains of the chicken neural cell adhesion molecule (N-CAM).

Authors: B A Murray; J J Hemperly; E A Prediger; G M Edelman; B A Cunningham
Journal: J Cell Biol Date: 1986-01 Impact factor: 10.539

9. A heparin-binding domain from N-CAM is involved in neural cell-substratum adhesion.

Authors: G J Cole; L Glaser
Journal: J Cell Biol Date: 1986-02 Impact factor: 10.539

10. Topography of N-CAM structural and functional determinants. I. Classification of monoclonal antibody epitopes.

Authors: M Watanabe; A L Frelinger; U Rutishauser
Journal: J Cell Biol Date: 1986-11 Impact factor: 10.539

26 in total

1. The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth.

Authors: K Takei; T A Chan; F S Wang; H Deng; U Rutishauser; D G Jay
Journal: J Neurosci Date: 1999-11-01 Impact factor: 6.167

2. Structural requirements for neural cell adhesion molecule-heparin interaction.

Authors: A A Reyes; R Akeson; L Brezina; G J Cole
Journal: Cell Regul Date: 1990-07

3. Selective innervation of fast and slow muscle regions during early chick neuromuscular development.

Authors: V F Rafuse; L D Milner; L T Landmesser
Journal: J Neurosci Date: 1996-11-01 Impact factor: 6.167

4. The pattern of avian intramuscular nerve branching is determined by the innervating motoneuron and its level of polysialic acid.

Authors: V F Rafuse; L T Landmesser
Journal: J Neurosci Date: 2000-02-01 Impact factor: 6.167

5. The effect of beta-bungarotoxin, or geniculate ganglion lesion on taste bud development in the chick embryo.

Authors: Donald Ganchrow; Judith Ganchrow; Martin Witt; Eve Arki-Burstyn
Journal: Histochem Cell Biol Date: 2006-05-31 Impact factor: 4.304

6. Analysis of cDNA clones that code for the transmembrane forms of the mouse neural cell adhesion molecule (NCAM) and are generated by alternative RNA splicing.

Authors: M J Santoni; D Barthels; J A Barbas; M R Hirsch; M Steinmetz; C Goridis; W Wille
Journal: Nucleic Acids Res Date: 1987-11-11 Impact factor: 16.971

7. Changes in neural cell adhesion molecule (NCAM) structure during vertebrate neural development.

Authors: J Sunshine; K Balak; U Rutishauser; M Jacobson
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

8. Vertical versus planar neural induction in Rana pipiens embryos.

Authors: J P Saint-Jeannet; I B Dawid
Journal: Proc Natl Acad Sci U S A Date: 1994-04-12 Impact factor: 11.205

9. Age-related changes in expression of the neural cell adhesion molecule in skeletal muscle: a comparative study of newborn, adult and aged rats.

Authors: A M Andersson; M Olsen; D Zhernosekov; H Gaardsvoll; L Krog; D Linnemann; E Bock
Journal: Biochem J Date: 1993-03-15 Impact factor: 3.857

10. Primary structure and developmental expression of a large cytoplasmic domain form of Xenopus laevis neural cell adhesion molecule (NCAM).

Authors: P A Krieg; D S Sakaguchi; C R Kintner
Journal: Nucleic Acids Res Date: 1989-12-25 Impact factor: 16.971